biostudies-literatureUnknown7(9)Otsubo T<h4>Background</h4>Atrial biopsy is technically challenging owing to the atria's thin walls and relatively thick endocardium. This study assessed the feasibility and safety of echocardiography-guided atrial biopsy in a consecutive cohort of 1,000 patients who underwent catheter ablation for atrial tachyarrhythmias or percutaneous left atrial (LA) appendage occlusion.<h4>Methods and results</h4>Atrial biopsy was performed at the limbus of the fossa ovalis through the femoral vein using a 5.5-Fr (n=233) or a 7.0-Fr (n=767) bioptome under intracardiac (n=963) or transesophageal (n=37) echocardiography guidance, alongside fluoroscopy. For histological analysis, 5 tissue samples were collected from the same site. Biopsy was successfully completed in 996 (99.6%) patients. Patients were divided bCirculation reports764-773https://www.ebi.ac.uk/biostudies/studies/S-EPMC12419951biostudies-literatureFeasibility and Safety of Atrial Biopsy　- Evidence From 1,000 Cases.PMC12419951Osako ROtsubo TFukui AShinzato KAoki SNakashima KNode KHirota KTakahashi YShichida SEdayoshi MNishimura YIto KSasano TTsuruta KKawano YKawaguchi AYamaguchi TYokoi KTakigawa MTakahashi NShintani-Domoto YNomura SMiyazaki KfalseFeasibility and Safety of Atrial Biopsy　- Evidence From 1,000 Cases.<h4>Background</h4>Atrial biopsy is technically challenging owing to the atria's thin walls and relatively thick endocardium. This study assessed the feasibility and safety of echocardiography-guided atrial biopsy in a consecutive cohort of 1,000 patients who underwent catheter ablation for atrial tachyarrhythmias or percutaneous left atrial (LA) appendage occlusion.<h4>Methods and results</h4>Atrial biopsy was performed at the limbus of the fossa ovalis through the femoral vein using a 5.5-Fr (n=233) or a 7.0-Fr (n=767) bioptome under intracardiac (n=963) or transesophageal (n=37) echocardiography guidance, alongside fluoroscopy. For histological analysis, 5 tissue samples were collected from the same site. Biopsy was successfully completed in 996 (99.6%) patients. Patients were divided b2025-01-01T00:00:00Z2025 Sep2026-06-02T17:37:50.282Z2026-04-18T03:11:54.129ZS-EPMC124199514093349610.1253/circrep.CR-25-0101