biostudies-literatureUnknown40(1)Afridi A<h4>Background</h4>The primary treatment for colorectal cancer, which is very prevalent, is surgery. Anastomotic leaking poses a significant risk following surgery. Intestinal perfusion can be objectively and instantly assessed with indocyanine green fluorescence imaging, which may lower leakage rates and enhance surgical results.<h4>Methods</h4>PubMed, Embase, and Web of Science databases were systematically searched using relevant keywords from inception until 5th of March 2025. Eight studies were included after final screening. Outcomes were reported as overall anastomotic leakage, wound infection, paralytic ileus, mechanical ileus, and post-operative hospital stay. Interstudy heterogeneity was assessed using I² and X² statistics (I² > 50% = significant International journal of colorectal disease193https://www.ebi.ac.uk/biostudies/studies/S-EPMC12420736biostudies-literatureEfficacy and safety of indocyanine green fluorescence imaging in colorectal cancer: a systematic review and meta-analysis of randomized controlled trials.PMC12420736Saleem YAfridi AKhan MHZulfiqar AIqbal AKhan HKhattak FBacha ZKamil KASajjad FAfridi RHabib HNisa FShahid IAli MAAfridi ZfalseEfficacy and safety of indocyanine green fluorescence imaging in colorectal cancer: a systematic review and meta-analysis of randomized controlled trials.<h4>Background</h4>The primary treatment for colorectal cancer, which is very prevalent, is surgery. Anastomotic leaking poses a significant risk following surgery. Intestinal perfusion can be objectively and instantly assessed with indocyanine green fluorescence imaging, which may lower leakage rates and enhance surgical results.<h4>Methods</h4>PubMed, Embase, and Web of Science databases were systematically searched using relevant keywords from inception until 5th of March 2025. Eight studies were included after final screening. Outcomes were reported as overall anastomotic leakage, wound infection, paralytic ileus, mechanical ileus, and post-operative hospital stay. Interstudy heterogeneity was assessed using I² and X² statistics (I² > 50% = significant 2025-01-01T00:00:00Z2025 Sep2026-06-02T20:35:46.086Z2026-05-27T03:08:18.064ZS-EPMC124207364092615210.1007/s00384-025-04941-7