{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["114(10)"],"submitter":["Heiring C"],"pubmed_abstract":["<h4>Aim</h4>To validate a prototype point-of-care (POC) test for the lecithin/sphingomyelin (L/S) ratio by identifying the optimal L/S cut-off for predicting surfactant need in preterm infants < 30 weeks' gestation using gastric aspirates (GAS) sampled at birth and to assess clinical feasibility.<h4>Methods</h4>GAS was sampled within 45 min of birth and analysed using the only available prototype POC L/S test. The primary outcome was the optimal L/S cut-off and diagnostic accuracy in predicting rescue surfactant treatment per European RDS guidelines, assessed by receiver operating characteristics. L/S results were blinded to clinicians. Due to a dispute between clinical investigators and patent holders, legal restrictions prohibit reporting of the primary outcome.<h4>Results</h4>Of 93 elig"],"journal":["Acta paediatrica (Oslo, Norway : 1992)"],"pagination":["2535-2542"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12420868"],"repository":["biostudies-literature"],"pubmed_title":["Predicting Surfactant Need at Birth: Failed Validation of a Bedside Method Using Gastric Aspirates."],"pmcid":["PMC12420868"],"pubmed_authors":["Agergaard P","Eckardt MC","Zachariassen G","Aunsholt L","Brink Henriksen T","Breindahl N","Viuff AC","Heiring C","Bender L","Poorisrisak P"],"additional_accession":[]},"is_claimable":false,"name":"Predicting Surfactant Need at Birth: Failed Validation of a Bedside Method Using Gastric Aspirates.","description":"<h4>Aim</h4>To validate a prototype point-of-care (POC) test for the lecithin/sphingomyelin (L/S) ratio by identifying the optimal L/S cut-off for predicting surfactant need in preterm infants < 30 weeks' gestation using gastric aspirates (GAS) sampled at birth and to assess clinical feasibility.<h4>Methods</h4>GAS was sampled within 45 min of birth and analysed using the only available prototype POC L/S test. The primary outcome was the optimal L/S cut-off and diagnostic accuracy in predicting rescue surfactant treatment per European RDS guidelines, assessed by receiver operating characteristics. L/S results were blinded to clinicians. Due to a dispute between clinical investigators and patent holders, legal restrictions prohibit reporting of the primary outcome.<h4>Results</h4>Of 93 elig","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Oct","modification":"2026-06-03T05:45:51.163Z","creation":"2026-04-25T03:14:40.163Z"},"accession":"S-EPMC12420868","cross_references":{"pubmed":["40346998"],"doi":["10.1111/apa.70128"]}}