biostudies-literatureUnknown114(10)Martello E<h4>Aim</h4>The aim of this review is to systematically summarise the evidence on the effectiveness of riboflavin (vitamin B2) or supplements containing riboflavin in preventing paediatric migraines.<h4>Methods</h4>This systematic review followed the Joanna Briggs Institute methodology and is reported to adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched multiple electronic databases on 25 October 2023 to identify potentially relevant studies. Studies were screened, critically appraised and data extracted by two reviewers. Data underwent a narrative synthesis using vote counting based on direction of effect and was presented using harvest plots.<h4>Results</h4>Seventeen studies of varying quality were included in the review. Riboflavin Acta paediatrica (Oslo, Norway : 1992)2443-2457https://www.ebi.ac.uk/biostudies/studies/S-EPMC12420874biostudies-literatureSystematic Review Suggests Nutraceuticals Containing Vitamin B2 Could Provide an Alternative Treatment for Paediatric Migraines.PMC12420874Ikechukwu PSeripenah PJoseph TKoboto DLeonardi-Bee JStewart-Evans JDhungana SWilson EMorling JRAiyelabegan FOrr JMartello EKinali MEmery HfalseSystematic Review Suggests Nutraceuticals Containing Vitamin B2 Could Provide an Alternative Treatment for Paediatric Migraines.<h4>Aim</h4>The aim of this review is to systematically summarise the evidence on the effectiveness of riboflavin (vitamin B2) or supplements containing riboflavin in preventing paediatric migraines.<h4>Methods</h4>This systematic review followed the Joanna Briggs Institute methodology and is reported to adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched multiple electronic databases on 25 October 2023 to identify potentially relevant studies. Studies were screened, critically appraised and data extracted by two reviewers. Data underwent a narrative synthesis using vote counting based on direction of effect and was presented using harvest plots.<h4>Results</h4>Seventeen studies of varying quality were included in the review. Riboflavin 2025-01-01T00:00:00Z2025 Oct2026-06-02T20:19:20.462Z2026-04-20T03:10:15.301ZS-EPMC124208744041124610.1111/apa.70157