{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["80(9)"],"submitter":["Creamer AW"],"funding":["Wellcome Trust"],"pubmed_abstract":["<h4>Background</h4>Prospective validation and comparison of the performance of nodule management protocols is limited. The aim of this study was to examine the performance of size and risk thresholds for assessing malignancy in solid nodules at baseline low-dose CT (LDCT) in a lung cancer screening (LCS) programme.<h4>Methods</h4>This was an observational study using data from the SUMMIT Study, a prospective longitudinal study investigating LDCT for LCS. Participants were 55-77 years old and met either the United States Preventative Services Task Force (2013) criteria or had a PLCO<sub>m2012</sub> risk of ≥1.3%. LDCTs were reported using computer-aided detection software (Veolity, MeVIS) with semiautomated volumetry. Cancer outcomes were reported for solid nodules reported at baseline CT, "],"journal":["Thorax"],"pagination":["624-631"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12421124"],"repository":["biostudies-literature"],"pubmed_title":["Performance of volume and diameter thresholds in malignancy prediction of solid nodules in lung cancer screening."],"pmcid":["PMC12421124"],"pubmed_authors":["Patel A","Parry-Billings K","O'Shaughnessy T","Cotton A","Clark M","Hanif Z","Miah M","Stefan E","Crossingham A","Taylor M","Teague J","Samson A","Verghese P","Jacob J","Patel U","Arancon D","Bhowmik A","Eng J","Sarpong R","Mehta S","Neville A","McEwen R","Mangera Z","Screaton N","Ellis S","Villanueva A","Gowers K","Airebamen J","Hackshaw A","Buchan T","Chan K","Hall H","Hacker AM","Quaife SL","Aziz T","Davies K","Janes SM","Nnorom S","Levermore C","Prendecki R","Phua K","Dawadi S","Ricketts WM","Khaw CR","El-Emir E","Lock S","Gyertson K","Beech N","Horst C","Tisi S","Creamer A","Perugia A","Bhamani A","Bojang F","Kiconco H","Ovayolu D","Zylstra J","Rusius J","Banka R","Hare S","Cash C","Sayer C","Navani N","Mullin AM","Rowlands J","Murali E","Pervez H","Ife C","McKee J","Enes SP","Robbie H","Gallagher L","Hosein C","Robinson P","Nundlall N","Devaraj A","Creamer AW","Green L","Anastasiadis T","Sennett K","Neville QA","Limani T","Dickson JL","Farrelly L","Ekeowa U","Bowyer V","SUMMIT Consortium","Callender T","Ruparel M","Hoque F","Edey A","McCabe J","Robinson G","Nair A","Suresh M"],"additional_accession":[]},"is_claimable":false,"name":"Performance of volume and diameter thresholds in malignancy prediction of solid nodules in lung cancer screening.","description":"<h4>Background</h4>Prospective validation and comparison of the performance of nodule management protocols is limited. The aim of this study was to examine the performance of size and risk thresholds for assessing malignancy in solid nodules at baseline low-dose CT (LDCT) in a lung cancer screening (LCS) programme.<h4>Methods</h4>This was an observational study using data from the SUMMIT Study, a prospective longitudinal study investigating LDCT for LCS. Participants were 55-77 years old and met either the United States Preventative Services Task Force (2013) criteria or had a PLCO<sub>m2012</sub> risk of ≥1.3%. LDCTs were reported using computer-aided detection software (Veolity, MeVIS) with semiautomated volumetry. Cancer outcomes were reported for solid nodules reported at baseline CT, ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-02T20:27:02.79Z","creation":"2026-04-20T03:10:16.606Z"},"accession":"S-EPMC12421124","cross_references":{"pubmed":["40456600"],"doi":["10.1136/thorax-2024-222086"]}}