{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(37)"],"submitter":["Li J"],"pubmed_abstract":["DNA with high storage density can serve as an alternative storage medium to respond to the global explosion of data growth and become a powerful personal storage memory if an integrated compact device can store and handle large-scale data. Here, we incorporate a DNA cassette tape with 5.5 × 10<sup>5</sup> addressable data partitions (addressing rate up to 1570 partitions per second), a DNA loading capacity of 28.6 mg per kilometer, and deposit-many-recover-many (DMRM) features per partition to flexibly manage large-scale storage data and achieve hundreds of years of data preservation. We develop a compact DNA cassette tape drive and verify its functionality by randomly depositing incomplete images into the data partition, demonstrating a completely automated closed-loop operation involving addressing, recovery, removal, subsequent file deposition, and file recovery again, all accomplished within 50 min. Last, the complete image is restored by next-generation sequencing and decoding. DNA cassette tape provides a strategy for fast, compact, large-scale DNA-based cold or warm data storage."],"journal":["Science advances"],"pagination":["eady3406"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12422178"],"repository":["biostudies-literature"],"pubmed_title":["A compact cassette tape for DNA-based data storage."],"pmcid":["PMC12422178"],"pubmed_authors":["Li X","Li J","Mao C","Shao J","Wang R","Wang S","Wang D","Jiang X","Zheng S","Luo X","Fan C"],"additional_accession":[]},"is_claimable":false,"name":"A compact cassette tape for DNA-based data storage.","description":"DNA with high storage density can serve as an alternative storage medium to respond to the global explosion of data growth and become a powerful personal storage memory if an integrated compact device can store and handle large-scale data. Here, we incorporate a DNA cassette tape with 5.5 × 10<sup>5</sup> addressable data partitions (addressing rate up to 1570 partitions per second), a DNA loading capacity of 28.6 mg per kilometer, and deposit-many-recover-many (DMRM) features per partition to flexibly manage large-scale storage data and achieve hundreds of years of data preservation. We develop a compact DNA cassette tape drive and verify its functionality by randomly depositing incomplete images into the data partition, demonstrating a completely automated closed-loop operation involving addressing, recovery, removal, subsequent file deposition, and file recovery again, all accomplished within 50 min. Last, the complete image is restored by next-generation sequencing and decoding. DNA cassette tape provides a strategy for fast, compact, large-scale DNA-based cold or warm data storage.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-02T20:26:22.607Z","creation":"2026-04-20T03:10:10.837Z"},"accession":"S-EPMC12422178","cross_references":{"pubmed":["40929263"],"doi":["10.1126/sciadv.ady3406"]}}