{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Matosevich N"],"funding":["European Research Council"],"pagination":["eadw6375"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12422181"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(37)"],"pubmed_abstract":["The locus coeruleus-norepinephrine (LC-NE) system regulates arousal and awakening; however, it remains unclear whether the LC does this in a global or circuit-specific manner. We hypothesized that sensory-evoked awakenings are predominantly regulated by specific LC-NE efferent pathways. Anatomical, physiological, and functional modularities of LC-NE pathways involving the mouse basal forebrain (BF) and pontine reticular nucleus (PRN) were tested. We found partial anatomical segregation between the <i>LC → PRN</i> and <i>LC → BF</i> circuits. Extracellular NE dynamics in BF and PRN exhibited distinct sound-evoked activation during sleep, including a fast sound-evoked NE peak specific to PRN. Causal optogenetic interrogation of LC efferent pathways, by retro-channelrhodopsin (ChR2) activatio"],"journal":["Science advances"],"pubmed_title":["An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening."],"pmcid":["PMC12422181"],"funding_grant_id":["864353"],"pubmed_authors":["Regev N","Kimchy U","Zelinger N","Marmelshtein A","Kabaha S","Nir Y","Gabay N","Matosevich N"],"additional_accession":[]},"is_claimable":false,"name":"An early surge of norepinephrine along brainstem pathways drives sensory-evoked awakening.","description":"The locus coeruleus-norepinephrine (LC-NE) system regulates arousal and awakening; however, it remains unclear whether the LC does this in a global or circuit-specific manner. We hypothesized that sensory-evoked awakenings are predominantly regulated by specific LC-NE efferent pathways. Anatomical, physiological, and functional modularities of LC-NE pathways involving the mouse basal forebrain (BF) and pontine reticular nucleus (PRN) were tested. We found partial anatomical segregation between the <i>LC → PRN</i> and <i>LC → BF</i> circuits. Extracellular NE dynamics in BF and PRN exhibited distinct sound-evoked activation during sleep, including a fast sound-evoked NE peak specific to PRN. Causal optogenetic interrogation of LC efferent pathways, by retro-channelrhodopsin (ChR2) activatio","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-02T20:27:10.83Z","creation":"2026-04-20T03:10:18.14Z"},"accession":"S-EPMC12422181","cross_references":{"pubmed":["40929279"],"doi":["10.1126/sciadv.adw6375"]}}