{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Yu C"],"pubmed_abstract":["<h4>Background</h4>Tumor-associated macrophages (TAMs) are a type of tumor-infiltrating immune cell that play a crucial role in tumor progression. However, the roles of TAMs and their regulatory mechanisms in lung adenocarcinoma (LUAD) remain poorly understood. Therefore, we aimed to develop a novel TAM-related prognostic signature to predict survival outcomes and constructed a lncRNA-miRNA-mRNA network based on these genes.<h4>Methods</h4>Transcriptomic data, clinical data, and single-cell RNA-sequencing (scRNA-seq) data were obtained from LUAD patients were obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Differentially expressed-lncRNAs (DE-lncRNAs), miRNAs (DE-miRNAs), and mRNAs (DEGs) were identified in LUAD. Differentially expressed TAM-relate"],"journal":["PeerJ"],"pagination":["e19920"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12422256"],"repository":["biostudies-literature"],"pubmed_title":["Integrative analyses of single-cell and bulk RNA sequencing to construct the tumor-associated macrophage-related prognostic signature in lung adenocarcinoma."],"pmcid":["PMC12422256"],"pubmed_authors":["Li H","Yu C","Chen J","Tian H","Zhuang Q","Deng J","Luo B","Ye H"],"additional_accession":[]},"is_claimable":false,"name":"Integrative analyses of single-cell and bulk RNA sequencing to construct the tumor-associated macrophage-related prognostic signature in lung adenocarcinoma.","description":"<h4>Background</h4>Tumor-associated macrophages (TAMs) are a type of tumor-infiltrating immune cell that play a crucial role in tumor progression. However, the roles of TAMs and their regulatory mechanisms in lung adenocarcinoma (LUAD) remain poorly understood. Therefore, we aimed to develop a novel TAM-related prognostic signature to predict survival outcomes and constructed a lncRNA-miRNA-mRNA network based on these genes.<h4>Methods</h4>Transcriptomic data, clinical data, and single-cell RNA-sequencing (scRNA-seq) data were obtained from LUAD patients were obtained from the Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. Differentially expressed-lncRNAs (DE-lncRNAs), miRNAs (DE-miRNAs), and mRNAs (DEGs) were identified in LUAD. Differentially expressed TAM-relate","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-04-20T03:12:30.789Z","creation":"2026-04-20T03:10:03.143Z"},"accession":"S-EPMC12422256","cross_references":{"pubmed":["40936758"],"doi":["10.7717/peerj.19920"]}}