biostudies-literatureYang RNational Key Research and Development ProgramNational Natural Science Foundation of ChinaCapital's Funds for Health Improvement and Research of Beijing2685-2693https://www.ebi.ac.uk/biostudies/studies/S-EPMC12423017biostudies-literatureUnknown42(8)<h4>Purpose</h4>To investigate if trophectoderm (TE) biopsy on preimplantation genetic testing (PGT) increases the risk of obstetrical and infant outcomes after frozen single blastocyst transfer cycles.<h4>Methods</h4>This retrospective cohort study included all frozen single blastocyst transfer cycles conducted between January 2012 and December 2017 at Peking University Third Hospital. A total of 1492 patients in the PGT group and 600 patients in the non-PGT group were analyzed. The primary outcomes were clinical pregnancy rate, live birth rate, and early motor development milestones. Secondary outcomes included miscarriage, obstetric complications, and infant outcomes.<h4>Results</h4>The PGT group had younger parental ages and higher antral follicle counts, whereas the non-PGT group had Journal of assisted reproduction and geneticsThe obstetrical and infant outcomes of trophectoderm biopsy on preimplantation genetic testing embryos after frozen single embryo transfer cycles.PMC12423017821716322022YFC27029052021YFC27006052024-2-409112024YFC2706702Li JChen LLiu PZhang NYang RTian THan ZLi RWang YWang JQiao JGao CfalseThe obstetrical and infant outcomes of trophectoderm biopsy on preimplantation genetic testing embryos after frozen single embryo transfer cycles.<h4>Purpose</h4>To investigate if trophectoderm (TE) biopsy on preimplantation genetic testing (PGT) increases the risk of obstetrical and infant outcomes after frozen single blastocyst transfer cycles.<h4>Methods</h4>This retrospective cohort study included all frozen single blastocyst transfer cycles conducted between January 2012 and December 2017 at Peking University Third Hospital. A total of 1492 patients in the PGT group and 600 patients in the non-PGT group were analyzed. The primary outcomes were clinical pregnancy rate, live birth rate, and early motor development milestones. Secondary outcomes included miscarriage, obstetric complications, and infant outcomes.<h4>Results</h4>The PGT group had younger parental ages and higher antral follicle counts, whereas the non-PGT group had 2025-01-01T00:00:00Z2025 Aug2026-06-01T23:29:33.761Z2026-05-23T03:08:12.501ZS-EPMC124230174063242410.1007/s10815-025-03512-7