biostudies-literatureHunter BNational Heart Foundation of Australia (Heart Foundation)Federal Government | DHAC | National Health and Medical Research CouncilNational Heart Foundation of AustraliaR.T. Hall TrustNIDDK NIH HHSR.T. Hall Trust (Estate of Late R.T. Hall)Federal Government | DHAC | National Health and Medical Research Council (NHMRC)NIH HHS2483-2524https://www.ebi.ac.uk/biostudies/studies/S-EPMC12423312biostudies-literatureUnknown17(9)Ischaemic cardiomyopathy is the most common cause of heart failure and often coexists with diabetes mellitus, which worsens patient symptom burden and outcomes. Yet, their combined effects are seldom investigated and are poorly understood. To uncover the influencing molecular signature defining ischaemic cardiomyopathy with diabetes, we performed multi-omic analyses of ischaemic and non-ischaemic cardiomyopathy with and without diabetes against healthy age-matched donors. Tissue was sourced from pre-mortem human left ventricular myocardium. Fatty acid transport and oxidation proteins were most downregulated in ischaemic cardiomyopathy with diabetes relative to donors. However, the downregulation of acylcarnitines, perilipin, and ketone body, amino acid, and glucose metabolising proteins inEMBO molecular medicineLeft ventricular myocardial molecular profile of human diabetic ischaemic cardiomyopathy.PMC124233121055952024161OT2 OD030544U2C DK119886RQ112104853G212785Khor JRajagopal VDutta SKoay YCMcEwen HO'Sullivan JFYang JYHMalecki CGuglielmi GLarance MZhang YWalker ADon ALal SHunter BHarney DHume RDPan MfalseLeft ventricular myocardial molecular profile of human diabetic ischaemic cardiomyopathy.Ischaemic cardiomyopathy is the most common cause of heart failure and often coexists with diabetes mellitus, which worsens patient symptom burden and outcomes. Yet, their combined effects are seldom investigated and are poorly understood. To uncover the influencing molecular signature defining ischaemic cardiomyopathy with diabetes, we performed multi-omic analyses of ischaemic and non-ischaemic cardiomyopathy with and without diabetes against healthy age-matched donors. Tissue was sourced from pre-mortem human left ventricular myocardium. Fatty acid transport and oxidation proteins were most downregulated in ischaemic cardiomyopathy with diabetes relative to donors. However, the downregulation of acylcarnitines, perilipin, and ketone body, amino acid, and glucose metabolising proteins in2025-01-01T00:00:00Z2025 Sep2026-06-01T23:28:10.462Z2026-05-23T03:08:04.258ZS-EPMC124233124075979310.1038/s44321-025-00281-9