{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pozzi C"],"funding":["Fondazione AIRC per la ricerca sul cancro ETS (AIRC)","Fondazione AIRC per la ricerca sul cancro ETS"],"pagination":["2215-2232"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12423316"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(9)"],"pubmed_abstract":["Identification of biomarkers for the hematogenous spreading of cancer cells is of paramount prognostic and therapeutic value. We showed that Plasmalemma Vesicle Associated Protein-1 (PV-1) serves as a marker of increased blood vessel permeability and is an independent predictor of colorectal cancer dissemination. This study investigates whether PV-1 can also act as a prognostic marker for distant metastases in other solid tumors. We analyzed samples from 134 patients: 30 luminal breast cancer (BC), 52 clear cell renal cell carcinoma (ccRCC), and obtained preliminary data from 52 soft tissue sarcomas (STS). A higher frequency of PV-1+ endothelial cells was significantly associated with metastatic progression in luminal BC and ccRCC. Moreover, the frequency of PV-1+ cells emerged as a signif"],"journal":["EMBO molecular medicine"],"pubmed_title":["PV-1: a novel molecular prognostic marker of distant metastases in various solid tumors."],"pmcid":["PMC12423316"],"funding_grant_id":["5x1000 2018 ID.21147","5x1000 2019 ID.22757"],"pubmed_authors":["Renne SL","Cananzi FCM","Pozzi C","Diana P","Sama L","Sarti R","Lo Cascio A","Bertuzzi A","Bonovas S","Lizier M","Tiraboschi L","Rescigno M","Fernandes B","Bertocchi A","Torrisi R","Tinterri C","Valeri M","Lazzeri M","Mazza EMC","Colombo P"],"additional_accession":[]},"is_claimable":false,"name":"PV-1: a novel molecular prognostic marker of distant metastases in various solid tumors.","description":"Identification of biomarkers for the hematogenous spreading of cancer cells is of paramount prognostic and therapeutic value. We showed that Plasmalemma Vesicle Associated Protein-1 (PV-1) serves as a marker of increased blood vessel permeability and is an independent predictor of colorectal cancer dissemination. This study investigates whether PV-1 can also act as a prognostic marker for distant metastases in other solid tumors. We analyzed samples from 134 patients: 30 luminal breast cancer (BC), 52 clear cell renal cell carcinoma (ccRCC), and obtained preliminary data from 52 soft tissue sarcomas (STS). A higher frequency of PV-1+ endothelial cells was significantly associated with metastatic progression in luminal BC and ccRCC. Moreover, the frequency of PV-1+ cells emerged as a signif","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T02:28:10.344Z","creation":"2026-04-23T03:10:44.923Z"},"accession":"S-EPMC12423316","cross_references":{"pubmed":["40691302"],"doi":["10.1038/s44321-025-00277-5"]}}