biostudies-literaturePozzi CFondazione AIRC per la ricerca sul cancro ETS (AIRC)Fondazione AIRC per la ricerca sul cancro ETS2215-2232https://www.ebi.ac.uk/biostudies/studies/S-EPMC12423316biostudies-literatureUnknown17(9)Identification of biomarkers for the hematogenous spreading of cancer cells is of paramount prognostic and therapeutic value. We showed that Plasmalemma Vesicle Associated Protein-1 (PV-1) serves as a marker of increased blood vessel permeability and is an independent predictor of colorectal cancer dissemination. This study investigates whether PV-1 can also act as a prognostic marker for distant metastases in other solid tumors. We analyzed samples from 134 patients: 30 luminal breast cancer (BC), 52 clear cell renal cell carcinoma (ccRCC), and obtained preliminary data from 52 soft tissue sarcomas (STS). A higher frequency of PV-1+ endothelial cells was significantly associated with metastatic progression in luminal BC and ccRCC. Moreover, the frequency of PV-1+ cells emerged as a signifEMBO molecular medicinePV-1: a novel molecular prognostic marker of distant metastases in various solid tumors.PMC124233165x1000 2018 ID.211475x1000 2019 ID.22757Renne SLCananzi FCMPozzi CDiana PSama LSarti RLo Cascio ABertuzzi ABonovas SLizier MTiraboschi LRescigno MFernandes BBertocchi ATorrisi RTinterri CValeri MLazzeri MMazza EMCColombo PfalsePV-1: a novel molecular prognostic marker of distant metastases in various solid tumors.Identification of biomarkers for the hematogenous spreading of cancer cells is of paramount prognostic and therapeutic value. We showed that Plasmalemma Vesicle Associated Protein-1 (PV-1) serves as a marker of increased blood vessel permeability and is an independent predictor of colorectal cancer dissemination. This study investigates whether PV-1 can also act as a prognostic marker for distant metastases in other solid tumors. We analyzed samples from 134 patients: 30 luminal breast cancer (BC), 52 clear cell renal cell carcinoma (ccRCC), and obtained preliminary data from 52 soft tissue sarcomas (STS). A higher frequency of PV-1+ endothelial cells was significantly associated with metastatic progression in luminal BC and ccRCC. Moreover, the frequency of PV-1+ cells emerged as a signif2025-01-01T00:00:00Z2025 Sep2026-06-03T02:28:10.344Z2026-04-23T03:10:44.923ZS-EPMC124233164069130210.1038/s44321-025-00277-5