{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(1)"],"submitter":["Mountain KE"],"funding":["Wellcome Trust"],"pubmed_abstract":["The mechanisms by which vaginal microbiota shape spontaneous preterm birth (sPTB) risk remain poorly defined. Using electronic clinical records data from 74,913 maternities in conjunction with metaxanomic (n = 596) and immune profiling (n = 314) data, we show that the B blood group phenotype associates with increased risk of sPTB and adverse vaginal microbiota composition. The O blood group associates with sPTB in women who have a combination of a previous history of sPTB, an adverse vaginal microbial composition and pro-inflammatory cervicovaginal milieu. In contrast, women of blood group A have a higher prevalence of vaginal Lactobacillus crispatus, a lower risk of sPTB, with sPTB cases showing no association with vaginal microbiota composition or inflammation. We found that cervicovagin"],"journal":["NPJ biofilms and microbiomes"],"pagination":["170"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12423329"],"repository":["biostudies-literature"],"pubmed_title":["ABO blood group antigens influence host-microbe interactions and risk of early spontaneous preterm birth."],"pmcid":["PMC12423329"],"pubmed_authors":["Tajadura-Ortega V","Hyde AKC","Brown RG","Feizi T","Glampson B","Dell A","Grassi P","Mayer E","Wu G","Sykes L","Haslam SM","Bennett PR","Mountain KE","Liu Y","Pasint-Magyar J","Teoh TG","Chai W","Lee YS","Marchesi JR","Stock SJ","Green A","Ng S","Terzidou V","David AL","Chan D","Gimeno-Molina B","MacIntyre DA","Lewis HV","Roberts LA","Norman JE","Kundu S"],"additional_accession":[]},"is_claimable":false,"name":"ABO blood group antigens influence host-microbe interactions and risk of early spontaneous preterm birth.","description":"The mechanisms by which vaginal microbiota shape spontaneous preterm birth (sPTB) risk remain poorly defined. Using electronic clinical records data from 74,913 maternities in conjunction with metaxanomic (n = 596) and immune profiling (n = 314) data, we show that the B blood group phenotype associates with increased risk of sPTB and adverse vaginal microbiota composition. The O blood group associates with sPTB in women who have a combination of a previous history of sPTB, an adverse vaginal microbial composition and pro-inflammatory cervicovaginal milieu. In contrast, women of blood group A have a higher prevalence of vaginal Lactobacillus crispatus, a lower risk of sPTB, with sPTB cases showing no association with vaginal microbiota composition or inflammation. We found that cervicovagin","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T07:43:33.251Z","creation":"2026-04-26T03:09:39.82Z"},"accession":"S-EPMC12423329","cross_references":{"pubmed":["40931094"],"doi":["10.1038/s41522-025-00783-x"]}}