{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tavares AH"],"funding":["National Institute of Diabetes and Digestive and Kidney Diseases","NIDDK NIH HHS","National Institutes of Health","Boston Nutrition Obesity Research Center, Boston University"],"pagination":["110563"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12423405"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["301(9)"],"pubmed_abstract":["White adipose tissue (WAT) fibrosis is a major determinant of obesity-induced cardiometabolic dysfunction and is characterized by excessive extracellular matrix deposition and myofibroblast activation. Transforming growth factor (TGF)-β1 is a profibrotic cytokine that potently induces myofibroblast activation in adipocyte stem cells (ASCs). How TGF-β1 orchestrates ASC activation in WAT fibrosis is not completely understood. We identified FOXS1, a member of the forkhead box transcription factor superfamily, as a transcriptional target of TGF-β1 signaling in primary human WAT ASC (hASC). FOXS1 potentiated TGF-β1-dependent upregulation of several myofibroblast genes (e.g. Acta2, Col1a1, Fn1, and Il11) in 10T1/2 fibroblasts. FOXS1 also attenuated the induction of several adipogenic factors (e."],"journal":["The Journal of biological chemistry"],"pubmed_title":["TGF-β1-dependent expression of FOXS1 attenuates adipogenic potential and enhances a myofibroblast cellular phenotype."],"pmcid":["PMC12423405"],"funding_grant_id":["P30 DK046200","R01DK132080","P30DK046200","R01 DK134534","T32DK007201","R01 DK132080","T32 DK007201","R01DK134534"],"pubmed_authors":["Layne MD","Zheng J","Tavares AH","Rabhi N","Connelly SP","Maksat D"],"additional_accession":[]},"is_claimable":false,"name":"TGF-β1-dependent expression of FOXS1 attenuates adipogenic potential and enhances a myofibroblast cellular phenotype.","description":"White adipose tissue (WAT) fibrosis is a major determinant of obesity-induced cardiometabolic dysfunction and is characterized by excessive extracellular matrix deposition and myofibroblast activation. Transforming growth factor (TGF)-β1 is a profibrotic cytokine that potently induces myofibroblast activation in adipocyte stem cells (ASCs). How TGF-β1 orchestrates ASC activation in WAT fibrosis is not completely understood. We identified FOXS1, a member of the forkhead box transcription factor superfamily, as a transcriptional target of TGF-β1 signaling in primary human WAT ASC (hASC). FOXS1 potentiated TGF-β1-dependent upregulation of several myofibroblast genes (e.g. Acta2, Col1a1, Fn1, and Il11) in 10T1/2 fibroblasts. FOXS1 also attenuated the induction of several adipogenic factors (e.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-06-03T02:51:36.712Z","creation":"2026-04-23T03:11:57.747Z"},"accession":"S-EPMC12423405","cross_references":{"pubmed":["40774386"],"doi":["10.1016/j.jbc.2025.110563"]}}