biostudies-literatureLi WCultivation Fund of Capital Medical UniversityBeijing Key Clinical Discipline FundBeijing Key Laboratory of Mental DisordersBeijing Scholar Program 2015 (Zhenchang Wang)China Scholarship CouncilNational Natural Science Foundation of ChinaBeijing Hospitals Authority Youth Programmee70859https://www.ebi.ac.uk/biostudies/studies/S-EPMC12423433biostudies-literatureUnknown15(9)<h4>Background</h4>Diverse correlations between structural brain abnormalities and the clinical feature of bulimia nervosa (BN) have been identified in previous observational studies.<h4>Objective</h4>To explore the bidirectional causality between BN and brain structural magnetic resonance imaging (MRI) phenotypes.<h4>Methods</h4>Genome-wide association studies (GWAS) of 2441 participants identified genetic variants associated with disordered eating and predicted BN, whereas UK Biobank 3D-T1 MRI data were used to analyze brain structural phenotypes. A bidirectional two-sample Mendelian randomization (MR) approach was used to investigate the causal relationships between BN and brain structural traits.<h4>Results</h4>The forward MR analysis showed that BN exerted a significant causal effect Brain and behaviorDissecting the Causal Association Between Bulimia Nervosa and Structural Brain Abnormalities: A Two-Sample Bidirectional Mendelian Randomization Study.PMC12423433(202308110230)(PYZ24061)(no. 2021-135)82001790(2021JSJB03)82302284(Grant No. QML20191902)Li WGrzegorzek MChen QTang LHuang XWang XWang YWang JWang ZZhang PfalseDissecting the Causal Association Between Bulimia Nervosa and Structural Brain Abnormalities: A Two-Sample Bidirectional Mendelian Randomization Study.<h4>Background</h4>Diverse correlations between structural brain abnormalities and the clinical feature of bulimia nervosa (BN) have been identified in previous observational studies.<h4>Objective</h4>To explore the bidirectional causality between BN and brain structural magnetic resonance imaging (MRI) phenotypes.<h4>Methods</h4>Genome-wide association studies (GWAS) of 2441 participants identified genetic variants associated with disordered eating and predicted BN, whereas UK Biobank 3D-T1 MRI data were used to analyze brain structural phenotypes. A bidirectional two-sample Mendelian randomization (MR) approach was used to investigate the causal relationships between BN and brain structural traits.<h4>Results</h4>The forward MR analysis showed that BN exerted a significant causal effect 2025-01-01T00:00:00Z2025 Sep2026-06-03T02:27:43.892Z2026-04-23T03:10:26.846ZS-EPMC124234334093154210.1002/brb3.70859