{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(35)"],"submitter":["Nguyen KV"],"pubmed_abstract":["Tetrahydropalmatine (THP) is the major bioactive alkaloid in <i>Stephania rotunda</i> Lour. (Menispermaceae) with well-known pharmacological properties, such as antiaddiction, antitumor, and neuroprotective activities. In this study, a novel ultrasonic-assisted extraction method for the sustainable extraction of the tetrahydropalmatine alkaloid from <i>S. rotunda</i> Lour. tubers was developed and optimized. The study reports also the development and validation of an HPLC-PDA analytical method intended for the quantification of THP in <i>S. rotunda</i> medicinal plant accompanied by a rapid and straightforward sample preparation procedure. A set of environmentally friendly and human-safe solvents was systematically evaluated for their extraction yield of THP, and the response surface metho"],"journal":["ACS omega"],"pagination":["40313-40323"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12423853"],"repository":["biostudies-literature"],"pubmed_title":["Sustainable Extraction of the Tetrahydropalmatine Alkaloid from &lt;i&gt;Stephania rotunda&lt;/i&gt; Lour. Tubers Using Eco-Friendly Solvent Systems."],"pmcid":["PMC12423853"],"pubmed_authors":["Nguyen LKT","Le NT","Ho DV","Raal A","Nguyen KV","Nguyen HT","Heinamaki J"],"additional_accession":[]},"is_claimable":false,"name":"Sustainable Extraction of the Tetrahydropalmatine Alkaloid from &lt;i&gt;Stephania rotunda&lt;/i&gt; Lour. Tubers Using Eco-Friendly Solvent Systems.","description":"Tetrahydropalmatine (THP) is the major bioactive alkaloid in <i>Stephania rotunda</i> Lour. (Menispermaceae) with well-known pharmacological properties, such as antiaddiction, antitumor, and neuroprotective activities. In this study, a novel ultrasonic-assisted extraction method for the sustainable extraction of the tetrahydropalmatine alkaloid from <i>S. rotunda</i> Lour. tubers was developed and optimized. The study reports also the development and validation of an HPLC-PDA analytical method intended for the quantification of THP in <i>S. rotunda</i> medicinal plant accompanied by a rapid and straightforward sample preparation procedure. A set of environmentally friendly and human-safe solvents was systematically evaluated for their extraction yield of THP, and the response surface metho","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-01T23:32:53.162Z","creation":"2026-05-24T03:07:07.631Z"},"accession":"S-EPMC12423853","cross_references":{"pubmed":["40949230"],"doi":["10.1021/acsomega.5c05568"]}}