{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Guo Q"],"funding":["Xiangya Hospital Central South University","Central South University","China Postdoctoral Science Foundation","National Natural Science Foundation of China","Hunan Provincial Natural Science Foundation"],"pagination":["113285"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12424239"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(9)"],"pubmed_abstract":["Age-related hearing loss (ARHL) is a major public health concern, driven by the interplay of multiple factors. Here, we reveal spatiotemporal metabolic shifts in murine inner ears mirroring erythrocytes and plasma. Isotope-labeled glucose tracing demonstrates a metabolic rerouting favoring glycolysis over the pentose phosphate pathway, alongside downregulation of the tricarboxylic acid cycle, indicating impaired energy production and redox homeostasis. Accumulation of medium- and long-chain acylcarnitines further exacerbates lipotoxicity. Notably, age-dependent depletion of arginine, lysine, proline, and glycine disrupts the arginine-polyamine-urea cycle. Translationally, UK Biobank plasma metabolomics links omega-6 fatty acids, linoleic acid, glycine, and albumin to ARHL resilience, while"],"journal":["iScience"],"pubmed_title":["Metabolic shifts in murine inner ears mimicking erythrocytes and plasma reveal diagnostics and early predictors for age-related hearing loss."],"pmcid":["PMC12424239"],"funding_grant_id":["82401827","82301514","2023JJ40919","2209090555464","GZB20240866","2025JJ60551","82400873","2023JJ41018","2023M743968","82230023"],"pubmed_authors":["Kellems RE","Xia Y","Li Z","Qiang Q","Long X","Zhang Y","Yu F","Luo C","Chen C","Wang Y","Guo Q","Liu W"],"additional_accession":[]},"is_claimable":false,"name":"Metabolic shifts in murine inner ears mimicking erythrocytes and plasma reveal diagnostics and early predictors for age-related hearing loss.","description":"Age-related hearing loss (ARHL) is a major public health concern, driven by the interplay of multiple factors. Here, we reveal spatiotemporal metabolic shifts in murine inner ears mirroring erythrocytes and plasma. Isotope-labeled glucose tracing demonstrates a metabolic rerouting favoring glycolysis over the pentose phosphate pathway, alongside downregulation of the tricarboxylic acid cycle, indicating impaired energy production and redox homeostasis. Accumulation of medium- and long-chain acylcarnitines further exacerbates lipotoxicity. Notably, age-dependent depletion of arginine, lysine, proline, and glycine disrupts the arginine-polyamine-urea cycle. Translationally, UK Biobank plasma metabolomics links omega-6 fatty acids, linoleic acid, glycine, and albumin to ARHL resilience, while","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T07:44:28.942Z","creation":"2026-04-26T03:09:49.327Z"},"accession":"S-EPMC12424239","cross_references":{"pubmed":["40949103"],"doi":["10.1016/j.isci.2025.113285"]}}