{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Han W"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS","NCI NIH HHS"],"pubmed_abstract":["Hematopoietic stem cell transplantation is a common treatment for many blood disorders and can be a life-saving therapy for patients with leukemias, lymphomas and multiple myeloma. Umbilical cord blood (UCB) serves as a valuable source of hematopoietic stem and progenitor cells (HSPCs) for transplantation, particularly for patients lacking a matched donor. However, the limited number of repopulating cells in UCB units restricts its clinical utility. Our prior studies showed that genetic deletion of the polycomb repressive complex 2 (PRC2) co-factor <i>Jarid2</i> in mouse multipotent progenitors (MPPs) conveyed ectopic self-renewal capacity. Here, we hypothesized that the function of human HSPCs could be enhanced through <i>JARID2</i> inhibition. In this study, we demonstrate that both cons"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.09.03.672211"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12424646"],"repository":["biostudies-literature"],"pubmed_title":["JARID2 Inhibition Reprograms Human Hematopoietic Progenitor Cells To Enhance Bone Marrow Transplantation."],"pmcid":["PMC12424646"],"funding_grant_id":["R01 HL147978","K99 HL165103","P30 CA091842","K99 CA296777","R01 DK119231","R01 DK124883","T32 HL007088","R01 HL152180"],"pubmed_authors":["Raj IX","Burkart SC","Rettig M","Han W","Celik H","Challen GA","Yang W","Li Y","Young AL","Magee JA","Zhang CR","Parsons TM","Arand J","Issa N","Bjeije H","Krishnan A"],"additional_accession":[]},"is_claimable":false,"name":"JARID2 Inhibition Reprograms Human Hematopoietic Progenitor Cells To Enhance Bone Marrow Transplantation.","description":"Hematopoietic stem cell transplantation is a common treatment for many blood disorders and can be a life-saving therapy for patients with leukemias, lymphomas and multiple myeloma. Umbilical cord blood (UCB) serves as a valuable source of hematopoietic stem and progenitor cells (HSPCs) for transplantation, particularly for patients lacking a matched donor. However, the limited number of repopulating cells in UCB units restricts its clinical utility. Our prior studies showed that genetic deletion of the polycomb repressive complex 2 (PRC2) co-factor <i>Jarid2</i> in mouse multipotent progenitors (MPPs) conveyed ectopic self-renewal capacity. Here, we hypothesized that the function of human HSPCs could be enhanced through <i>JARID2</i> inhibition. In this study, we demonstrate that both cons","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-04-29T03:22:09.654Z","creation":"2026-04-29T03:13:11.143Z"},"accession":"S-EPMC12424646","cross_references":{"pubmed":["40950155"],"doi":["10.1101/2025.09.03.672211"]}}