biostudies-literatureUnknownHan WNIDDK NIH HHSNHLBI NIH HHSNCI NIH HHSHematopoietic stem cell transplantation is a common treatment for many blood disorders and can be a life-saving therapy for patients with leukemias, lymphomas and multiple myeloma. Umbilical cord blood (UCB) serves as a valuable source of hematopoietic stem and progenitor cells (HSPCs) for transplantation, particularly for patients lacking a matched donor. However, the limited number of repopulating cells in UCB units restricts its clinical utility. Our prior studies showed that genetic deletion of the polycomb repressive complex 2 (PRC2) co-factor <i>Jarid2</i> in mouse multipotent progenitors (MPPs) conveyed ectopic self-renewal capacity. Here, we hypothesized that the function of human HSPCs could be enhanced through <i>JARID2</i> inhibition. In this study, we demonstrate that both consbioRxiv : the preprint server for biology2025.09.03.672211https://www.ebi.ac.uk/biostudies/studies/S-EPMC12424646biostudies-literatureJARID2 Inhibition Reprograms Human Hematopoietic Progenitor Cells To Enhance Bone Marrow Transplantation.PMC12424646R01 HL147978K99 HL165103P30 CA091842K99 CA296777R01 DK119231R01 DK124883T32 HL007088R01 HL152180Raj IXBurkart SCRettig MHan WCelik HChallen GAYang WLi YYoung ALMagee JAZhang CRParsons TMArand JIssa NBjeije HKrishnan AfalseJARID2 Inhibition Reprograms Human Hematopoietic Progenitor Cells To Enhance Bone Marrow Transplantation.Hematopoietic stem cell transplantation is a common treatment for many blood disorders and can be a life-saving therapy for patients with leukemias, lymphomas and multiple myeloma. Umbilical cord blood (UCB) serves as a valuable source of hematopoietic stem and progenitor cells (HSPCs) for transplantation, particularly for patients lacking a matched donor. However, the limited number of repopulating cells in UCB units restricts its clinical utility. Our prior studies showed that genetic deletion of the polycomb repressive complex 2 (PRC2) co-factor <i>Jarid2</i> in mouse multipotent progenitors (MPPs) conveyed ectopic self-renewal capacity. Here, we hypothesized that the function of human HSPCs could be enhanced through <i>JARID2</i> inhibition. In this study, we demonstrate that both cons2025-01-01T00:00:00Z2025 Sep2026-04-29T03:22:09.654Z2026-04-29T03:13:11.143ZS-EPMC124246464095015510.1101/2025.09.03.672211