{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Jo KB"],"funding":["NCI NIH HHS"],"pubmed_abstract":["Cancer drug resistance remains a major barrier to durable treatment success, often leading to relapse despite advances in precision oncology. While combination therapies are being increasingly investigated, such as chemotherapy with small molecule inhibitors, predicting drug response and identifying rational drug combinations based on resistance mechanisms remain major challenges. Therefore, a proteome-wide, single-gene overexpression screening platform is essential for guiding rational therapy selection. Here, we present <b>BOGO</b> (<b>B</b>xb1-landing pad human <b>O</b>RFeome-integrated system for a proteome-wide <b>G</b>ene <b>O</b>verexpression), a robust, scalable, and reproducible screening platform that enables single-copy, site-specific integration and overexpression of ~19,000 hu"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2025.09.02.673780"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12424776"],"repository":["biostudies-literature"],"pubmed_title":["BOGO: A Proteome-Wide Gene Overexpression Platform for Discovering Rational Cancer Combination Therapies."],"pmcid":["PMC12424776"],"funding_grant_id":["R21 CA259719"],"pubmed_authors":["Park JE","Roth FP","Kim H","Guo Y","Wright JP","Kim DE","Koh Y","Lee H","Kim DK","Kim JS","You K","Hill DE","Sane S","Cote AG","Jo KB","Lim HJ","Alruwaili MM","Choi JH","Matreyek KA","Naranjo MN","Bakin AV","Farh KK"],"additional_accession":[]},"is_claimable":false,"name":"BOGO: A Proteome-Wide Gene Overexpression Platform for Discovering Rational Cancer Combination Therapies.","description":"Cancer drug resistance remains a major barrier to durable treatment success, often leading to relapse despite advances in precision oncology. While combination therapies are being increasingly investigated, such as chemotherapy with small molecule inhibitors, predicting drug response and identifying rational drug combinations based on resistance mechanisms remain major challenges. Therefore, a proteome-wide, single-gene overexpression screening platform is essential for guiding rational therapy selection. Here, we present <b>BOGO</b> (<b>B</b>xb1-landing pad human <b>O</b>RFeome-integrated system for a proteome-wide <b>G</b>ene <b>O</b>verexpression), a robust, scalable, and reproducible screening platform that enables single-copy, site-specific integration and overexpression of ~19,000 hu","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-26T03:07:23.985Z","creation":"2026-05-26T03:06:24.911Z"},"accession":"S-EPMC12424776","cross_references":{"pubmed":["40950237"],"doi":["10.1101/2025.09.02.673780"]}}