{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Gervais A"],"funding":["NCATS NIH HHS","NIAID NIH HHS"],"pubmed_abstract":["Mosquito-borne West Nile virus (WNV) infection is a growing global health problem. About 0.5% of infected individuals develop encephalitis. We previously showed that 40% of patients in six cohorts had WNV encephalitis because of circulating auto-antibodies (auto-Abs) neutralizing type I IFNs. In seven new cohorts, we found that the prevalence of auto-Abs was highest (40% [17-44%]) in patients with encephalitis, and very low in a small sample of individuals with asymptomatic or mild infection. In the 13 European, Middle-Eastern and American cohorts available, odds ratios for WNV encephalitis in individuals with these auto-Abs relative to those without them in a large sample of the general population untested for WNV infection range from ~20 (OR=17.7; 95% CI: 13.8-22.8, <i>p</i><10<sup>-16</"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2025.08.31.25334556"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12424919"],"repository":["biostudies-literature"],"pubmed_title":["Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephalitis in seven new cohorts."],"pmcid":["PMC12424919"],"funding_grant_id":["R01 AI091707","R01 AI124690","R01 AI091816","R01 AI163029","UL1 TR001866","U19 AI089992"],"pubmed_authors":["Lazzarotto T","Comoli P","Vogiatzis S","Puel A","Barzon L","Freund T","Angelini M","Gervais A","Borghesi A","Dolci A","Cereda D","Rossini G","Lilleri D","Cassaniti I","Ghisetti V","Bastard P","Pacenti M","Abel L","Casanova JL","Mileto D","Codullo V","Aubart M","Gadoth A","MacDonald MR","Croce S","Stiasny K","Aberle JH","Nagy A","Simonin Y","Bizien L","Baldanti F","Paran Y","Aiuti A","Florian DM","Zhang SY","Ferrari A","Conti F","Fellay J","Hagin D","Cobat A","Piralla A","Jouanguy E","Moratti M","Murray KO","Trespidi F","Uhrlaub JL","Zecca M","Marchal A","Rovida F","Biran R","Avanzini MA","Lucca C","Mancon A","Rice CM","Burdino E"],"additional_accession":[]},"is_claimable":false,"name":"Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephalitis in seven new cohorts.","description":"Mosquito-borne West Nile virus (WNV) infection is a growing global health problem. About 0.5% of infected individuals develop encephalitis. We previously showed that 40% of patients in six cohorts had WNV encephalitis because of circulating auto-antibodies (auto-Abs) neutralizing type I IFNs. In seven new cohorts, we found that the prevalence of auto-Abs was highest (40% [17-44%]) in patients with encephalitis, and very low in a small sample of individuals with asymptomatic or mild infection. In the 13 European, Middle-Eastern and American cohorts available, odds ratios for WNV encephalitis in individuals with these auto-Abs relative to those without them in a large sample of the general population untested for WNV infection range from ~20 (OR=17.7; 95% CI: 13.8-22.8, <i>p</i><10<sup>-16</","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-05-26T20:06:38.3Z","creation":"2026-05-26T03:06:26.634Z"},"accession":"S-EPMC12424919","cross_references":{"pubmed":["40950468"],"doi":["10.1101/2025.08.31.25334556"]}}