{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li Y"],"funding":["Natural Science Foundation of Hunan Province","Beijing Health Promotion Association","National Key Research and Development Program of China"],"pagination":["e0328743"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12425316"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(9)"],"pubmed_abstract":["<h4>Background</h4>Extensive research has demonstrated the detrimental effects of COVID-19 on maternal-fetal outcomes. However, few studies have examined the impact of SARS-CoV-2 infection before and during organogenesis on human embryo implantation and subsequent development. Additionally, the influence of SARS-CoV-2 on the endometrial microenvironment, which is critical for embryo implantation, remains poorly understood. This study seeks to address these gaps in knowledge.<h4>Methods and findings</h4>We prospectively enrolled 971 participants undergoing frozen-thawed embryo transfer (FET) during the final two months of 2022, coinciding with the nationwide COVID19 outbreak following the end of China's Zero-Covid policy. Patients undergoing FET during this period were at high risk of SARS-"],"journal":["PloS one"],"pubmed_title":["Influence of SARS-CoV-2 infection before and during organogenesis on embryo implantation and development outcomes: A prospective cohort observational study."],"pmcid":["PMC12425316"],"funding_grant_id":["BJHPA-2022-SHZHYXZHQNYJ-JICH-006","2022JJ30983","2021YFC2700404"],"pubmed_authors":["Li Y","Lu X","Zhang J","Liao H","Huang X","Fu J","Yang F","Zhang Q","Mao Z"],"additional_accession":[]},"is_claimable":false,"name":"Influence of SARS-CoV-2 infection before and during organogenesis on embryo implantation and development outcomes: A prospective cohort observational study.","description":"<h4>Background</h4>Extensive research has demonstrated the detrimental effects of COVID-19 on maternal-fetal outcomes. However, few studies have examined the impact of SARS-CoV-2 infection before and during organogenesis on human embryo implantation and subsequent development. Additionally, the influence of SARS-CoV-2 on the endometrial microenvironment, which is critical for embryo implantation, remains poorly understood. This study seeks to address these gaps in knowledge.<h4>Methods and findings</h4>We prospectively enrolled 971 participants undergoing frozen-thawed embryo transfer (FET) during the final two months of 2022, coinciding with the nationwide COVID19 outbreak following the end of China's Zero-Covid policy. Patients undergoing FET during this period were at high risk of SARS-","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-03T02:30:03.427Z","creation":"2026-04-23T03:10:07.779Z"},"accession":"S-EPMC12425316","cross_references":{"pubmed":["40934174"],"doi":["10.1371/journal.pone.0328743"]}}