{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang M"],"funding":["This research was funded by the Hangzhou Science and Technology Bureau, guided by the project (China), grant number 20220919Y035."],"pagination":["e70832"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12425818"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29(17)"],"pubmed_abstract":["To characterise T-cell immunity and inflammatory profiles in HIV patients with mycobacterial co-infections. This study enrolled 41 HIV patients co-infected with Mycobacterium tuberculosis (HIV-TB, n = 27) or non-tuberculous mycobacteria (HIV-NTM, n = 14), along with 30 controls (20 HIV-monoinfected, 10 post-treatment) from a single centre. Flow cytometry quantified T-cell subsets (CD3 + CD4+, CD3 + CD8+, CD28+ subsets), mitochondrial parameters (mass [MM], low membrane potential [MMP-low%]) and cytokines (IFN-γ, IL-2/4/6/10/17A, TNF-α). Co-infected groups showed reduced T-cell counts versus HIV-monoinfected controls (p < 0.05). Elevated MMP-low% in CD3 + CD4+/CD28+ T cells indicated mitochondrial dysfunction in co-infected patients (p < 0.05). HIV-TB patients exhibited higher CD3 + CD4+/CD"],"journal":["Journal of cellular and molecular medicine"],"pubmed_title":["Altered T Lymphocytes Mitochondrial Function and Inflammatory Factors of Peripheral Blood in HIV Patients With Mycobacterial Infection."],"pmcid":["PMC12425818"],"funding_grant_id":["20220919Y035"],"pubmed_authors":["Wang M","Yan J","Dong X","Hui L","Chen W","Wan H","Liu S","Shi J"],"additional_accession":[]},"is_claimable":false,"name":"Altered T Lymphocytes Mitochondrial Function and Inflammatory Factors of Peripheral Blood in HIV Patients With Mycobacterial Infection.","description":"To characterise T-cell immunity and inflammatory profiles in HIV patients with mycobacterial co-infections. This study enrolled 41 HIV patients co-infected with Mycobacterium tuberculosis (HIV-TB, n = 27) or non-tuberculous mycobacteria (HIV-NTM, n = 14), along with 30 controls (20 HIV-monoinfected, 10 post-treatment) from a single centre. Flow cytometry quantified T-cell subsets (CD3 + CD4+, CD3 + CD8+, CD28+ subsets), mitochondrial parameters (mass [MM], low membrane potential [MMP-low%]) and cytokines (IFN-γ, IL-2/4/6/10/17A, TNF-α). Co-infected groups showed reduced T-cell counts versus HIV-monoinfected controls (p < 0.05). Elevated MMP-low% in CD3 + CD4+/CD28+ T cells indicated mitochondrial dysfunction in co-infected patients (p < 0.05). HIV-TB patients exhibited higher CD3 + CD4+/CD","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-04-08T19:52:34.67Z","creation":"2026-04-08T14:34:38.706Z"},"accession":"S-EPMC12425818","cross_references":{"pubmed":["40936199"],"doi":["10.1111/jcmm.70832"]}}