{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Park DD"],"pubmed_abstract":["<h4>Introduction</h4>The molecular mechanisms regulating cardiomyocyte (CM) proliferation during heart development are essential for understanding regenerative processes but remain incompletely defined. While adult mammalian CMs are post-mitotic, zebrafish retain proliferative capacity throughout life. We aimed to identify genetic regulators that fine-tune CM proliferation during cardiac development.<h4>Methods</h4>Using an N-ethyl-N-nitrosourea (ENU) mutagenesis screen in zebrafish, we identified the embryonic-lethal mutant <i>heart of stone (hos)</i>, which exhibits cardiac hyperplasia. Genetic mapping revealed a point mutation in <i>smarce1</i>, a component of the SWI/SNF chromatin remodeling complex. We performed morpholino knockdown, mRNA rescue, and Tet-On-driven myocardium-specific "],"journal":["Frontiers in cell and developmental biology"],"pagination":["1636944"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12426013"],"repository":["biostudies-literature"],"pubmed_title":["Smarce1 fine-tunes cardiomyocyte proliferation in the embryonic zebrafish heart."],"pmcid":["PMC12426013"],"pubmed_authors":["Rottbauer W","Krieg L","Just S","Park DD","Dahme T"],"additional_accession":[]},"is_claimable":false,"name":"Smarce1 fine-tunes cardiomyocyte proliferation in the embryonic zebrafish heart.","description":"<h4>Introduction</h4>The molecular mechanisms regulating cardiomyocyte (CM) proliferation during heart development are essential for understanding regenerative processes but remain incompletely defined. While adult mammalian CMs are post-mitotic, zebrafish retain proliferative capacity throughout life. We aimed to identify genetic regulators that fine-tune CM proliferation during cardiac development.<h4>Methods</h4>Using an N-ethyl-N-nitrosourea (ENU) mutagenesis screen in zebrafish, we identified the embryonic-lethal mutant <i>heart of stone (hos)</i>, which exhibits cardiac hyperplasia. Genetic mapping revealed a point mutation in <i>smarce1</i>, a component of the SWI/SNF chromatin remodeling complex. We performed morpholino knockdown, mRNA rescue, and Tet-On-driven myocardium-specific ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-01T12:05:02.14Z","creation":"2026-04-08T12:05:43.153Z"},"accession":"S-EPMC12426013","cross_references":{"pubmed":["40950410"],"doi":["10.3389/fcell.2025.1636944"]}}