biostudies-literatureUnknown16Kardaras FS<h4>Background</h4>The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted extensive research into factors influencing the onset and severity of the disease. Among these factors, the role of the nasopharyngeal microbiome, a vital ecosystem critical for respiratory health and immune modulation, remains incompletely understood. This study aimed to elucidate the relationship between the composition of nasopharyngeal microbiota and the clinical presentation of COVID-19 during the initial phase of infection.<h4>Materials and methods</h4>A total of 81 nasopharyngeal swab samples were collected from individuals in Central Greece between January and February 2021. Following quality control, 77 samples were selected for Frontiers in microbiology1631198https://www.ebi.ac.uk/biostudies/studies/S-EPMC12426191biostudies-literatureIdentification of nasopharyngeal microbial dysbiosis in COVID-19 patients by 16S rRNA gene sequencing.PMC12426191Kardaras FSTsilipounidaki KHatzigeorgiou AGSiatravani EPetinaki EMiriagou VfalseIdentification of nasopharyngeal microbial dysbiosis in COVID-19 patients by 16S rRNA gene sequencing.<h4>Background</h4>The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has prompted extensive research into factors influencing the onset and severity of the disease. Among these factors, the role of the nasopharyngeal microbiome, a vital ecosystem critical for respiratory health and immune modulation, remains incompletely understood. This study aimed to elucidate the relationship between the composition of nasopharyngeal microbiota and the clinical presentation of COVID-19 during the initial phase of infection.<h4>Materials and methods</h4>A total of 81 nasopharyngeal swab samples were collected from individuals in Central Greece between January and February 2021. Following quality control, 77 samples were selected for 2025-01-01T00:00:00Z20252026-06-03T02:51:34.777Z2026-04-23T03:11:56.85ZS-EPMC124261914095058510.3389/fmicb.2025.1631198