biostudies-literatureUnknown30(26)Kim DY<h4>Background</h4>Paragangliomas are rare neuroendocrine tumors arising from chromaffin cells, often associated with excess catecholamine production. Cardiac paragangliomas are particularly uncommon, accounting for <1% of all cardiac tumors.<h4>Case summary</h4>We report a case of a right ventricular mass that was initially misidentified as a pericardial cyst on imaging but was ultimately diagnosed as a benign paraganglioma deriving from hereditary paraganglioma and pheochromocytoma syndrome after further diagnostic evaluation and treatment.<h4>Discussion</h4>This case highlights how rare pathologies may mimic other conditions, emphasizing the complexity and importance of a thorough diagnostic work-up in identifying cardiac paragangliomas.<h4>Take-home messages</h4>Cardiac paragangliomas JACC. Case reports104892https://www.ebi.ac.uk/biostudies/studies/S-EPMC12426667biostudies-literatureRight Ventricular Paraganglioma Mimicking Coronary Artery Aneurysm: A Diagnostic Conundrum.PMC12426667Jenkins WTKim DYShah PPrasad RAnand UAlkhatib DAzarkhail RfalseRight Ventricular Paraganglioma Mimicking Coronary Artery Aneurysm: A Diagnostic Conundrum.<h4>Background</h4>Paragangliomas are rare neuroendocrine tumors arising from chromaffin cells, often associated with excess catecholamine production. Cardiac paragangliomas are particularly uncommon, accounting for <1% of all cardiac tumors.<h4>Case summary</h4>We report a case of a right ventricular mass that was initially misidentified as a pericardial cyst on imaging but was ultimately diagnosed as a benign paraganglioma deriving from hereditary paraganglioma and pheochromocytoma syndrome after further diagnostic evaluation and treatment.<h4>Discussion</h4>This case highlights how rare pathologies may mimic other conditions, emphasizing the complexity and importance of a thorough diagnostic work-up in identifying cardiac paragangliomas.<h4>Take-home messages</h4>Cardiac paragangliomas 2025-01-01T00:00:00Z2025 Sep2026-04-08T19:12:36.973Z2026-04-08T12:04:42.595ZS-EPMC124266674091284410.1016/j.jaccas.2025.104892