biostudies-literatureLee KHNational Research Foundation of Koreae70052https://www.ebi.ac.uk/biostudies/studies/S-EPMC12426705biostudies-literatureUnknown34(5)We examined the neural basis of emotion regulation in shift workers, and the relationships between the neural basis of emotion regulation, mood, sleep disturbance and 24-h rest-activity rhythm (RAR). Fifty-six shift workers (SW) with non-standard shift schedules and 52 controls (CON) participated in this study. They completed self-reported measures of sleep and mood problems, kept a sleep diary, and wore a wrist actigraphy device to assess sleep and 24-h RAR. They underwent one-night polysomnography and were scanned while performing an emotion regulation task. We examined group differences in the neural basis of emotion regulation and correlations between neural, mood, sleep and 24-h RAR variables. SW showed greater sleep disturbance (i.e., lower actigraphy-estimated sleep efficiency) and Journal of sleep researchTwenty-Four Hour Rest-Activity Rhythm Disturbances and Neural Alterations Associated With Emotion Regulation in Shift Workers.PMC12426705RS‐2024‐00457381RS-2024-004573812022R1A2C1008209Lee MHJeon JELee HYLee JShin JLee YJSeo MCKim SJLee KHfalseTwenty-Four Hour Rest-Activity Rhythm Disturbances and Neural Alterations Associated With Emotion Regulation in Shift Workers.We examined the neural basis of emotion regulation in shift workers, and the relationships between the neural basis of emotion regulation, mood, sleep disturbance and 24-h rest-activity rhythm (RAR). Fifty-six shift workers (SW) with non-standard shift schedules and 52 controls (CON) participated in this study. They completed self-reported measures of sleep and mood problems, kept a sleep diary, and wore a wrist actigraphy device to assess sleep and 24-h RAR. They underwent one-night polysomnography and were scanned while performing an emotion regulation task. We examined group differences in the neural basis of emotion regulation and correlations between neural, mood, sleep and 24-h RAR variables. SW showed greater sleep disturbance (i.e., lower actigraphy-estimated sleep efficiency) and 2025-01-01T00:00:00Z2025 Oct2026-06-01T06:32:47.534Z2026-04-08T10:05:27.856ZS-EPMC124267054018088510.1111/jsr.70052