{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kang Z"],"funding":["Natural Science Foundation of Guangdong Province, China","Nanfang Hospital Ethics Committee"],"pagination":["2558123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12427475"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["57(1)"],"pubmed_abstract":["<h4>Background</h4>AIDS-related non-Hodgkin lymphoma (AR-NHL), a leading malignancy among people living with HIV (PLWH), may not receive standard intensive curative therapies as the general population due to immune deficiency concerns, even in the combined antiretroviral therapy (cART) and immunochemotherapy era. Thus, a comprehensive understanding of T-cell subsets landscapes is urgently needed to grasp the complex and dynamic role of the immune system in AR-NHL patients' survival.<h4>Materials and methods</h4>This longitudinal cohort study enrolled 31 <i>de novo</i> adult AR-NHL patients and 52 HIV-negative NHL controls. Multi-color flow cytometry profiled peripheral blood immunophenotypes at baseline and during immunochemotherapy. Univariate and multivariate Cox regression analyses eval"],"journal":["Annals of medicine"],"pubmed_title":["Immunosenescence phenotypes and prognostic significance of CD8 + CD28- T cells in AIDS-related non-Hodgkin lymphoma."],"pmcid":["PMC12427475"],"funding_grant_id":["2023A1515030252","NFEC-2021-178"],"pubmed_authors":["Chu S","Chen J","Tao X","Wu S","Kang Z","Peng J"],"additional_accession":[]},"is_claimable":false,"name":"Immunosenescence phenotypes and prognostic significance of CD8 + CD28- T cells in AIDS-related non-Hodgkin lymphoma.","description":"<h4>Background</h4>AIDS-related non-Hodgkin lymphoma (AR-NHL), a leading malignancy among people living with HIV (PLWH), may not receive standard intensive curative therapies as the general population due to immune deficiency concerns, even in the combined antiretroviral therapy (cART) and immunochemotherapy era. Thus, a comprehensive understanding of T-cell subsets landscapes is urgently needed to grasp the complex and dynamic role of the immune system in AR-NHL patients' survival.<h4>Materials and methods</h4>This longitudinal cohort study enrolled 31 <i>de novo</i> adult AR-NHL patients and 52 HIV-negative NHL controls. Multi-color flow cytometry profiled peripheral blood immunophenotypes at baseline and during immunochemotherapy. Univariate and multivariate Cox regression analyses eval","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-02T10:06:28.808Z","creation":"2026-05-26T03:06:42.247Z"},"accession":"S-EPMC12427475","cross_references":{"pubmed":["40932058"],"doi":["10.1080/07853890.2025.2558123"]}}