{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Baumges H"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["1355"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12427801"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(17)"],"pubmed_abstract":["Fucose-containing glycoproteins and glycolipids broadly occur in humans as well as in many other species and are essential for a wide range of physiological processes, such as cell adhesion, fertilization, and tumor development. In humans, the cellular degradation of various fucosylated glycoconjugates depends on the <i>FUCA1</i>-encoded lysosomal tissue α-L-fucosidase (FUCA1). The crucial role of FUCA1 is reflected by the severe lysosomal storage disease fucosidosis, which causes a massive accumulation of fucosylated glycans, glycolipids, and α(1,6)-fucosylated glycoasparagines. Therefore, it is reasonable to assume that FUCA1 is predominantly responsible for the degradation of fucosylated glycoconjugates, although a second, functionally uncharacterized α-L-fucosidase, the plasma α-L-fuco"],"journal":["Cells"],"pubmed_title":["Deciphering α-L-Fucosidase Activity Contribution in Human and Mouse: Tissue α-L-Fucosidase FUCA1 Meets Plasma α-L-Fucosidase FUCA2."],"pmcid":["PMC12427801"],"funding_grant_id":["FOR2625 TP7"],"pubmed_authors":["Lubke T","Lange H","Hausser JA","Markmann S","Braulke T","Jelinek S","Ilse MB","Baumges H","Capriotti E"],"additional_accession":[]},"is_claimable":false,"name":"Deciphering α-L-Fucosidase Activity Contribution in Human and Mouse: Tissue α-L-Fucosidase FUCA1 Meets Plasma α-L-Fucosidase FUCA2.","description":"Fucose-containing glycoproteins and glycolipids broadly occur in humans as well as in many other species and are essential for a wide range of physiological processes, such as cell adhesion, fertilization, and tumor development. In humans, the cellular degradation of various fucosylated glycoconjugates depends on the <i>FUCA1</i>-encoded lysosomal tissue α-L-fucosidase (FUCA1). The crucial role of FUCA1 is reflected by the severe lysosomal storage disease fucosidosis, which causes a massive accumulation of fucosylated glycans, glycolipids, and α(1,6)-fucosylated glycoasparagines. Therefore, it is reasonable to assume that FUCA1 is predominantly responsible for the degradation of fucosylated glycoconjugates, although a second, functionally uncharacterized α-L-fucosidase, the plasma α-L-fuco","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-08T19:55:29.524Z","creation":"2026-04-08T14:35:10.568Z"},"accession":"S-EPMC12427801","cross_references":{"pubmed":["40940767"],"doi":["10.3390/cells14171355"]}}