{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Z"],"funding":["USDA"],"pagination":["8310"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12428041"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(17)"],"pubmed_abstract":["Seed size is a key trait affecting evolution and agronomic performance by influencing seedling establishment in natural populations and crop yields. The <i>Arabidopsis thaliana</i> Seed Size QTL1 (SSQ1) locus explains 10-15% of the variation in seed size. We report here that the causal gene for this locus is <i>Tetratricopeptide Repeat Protein 2</i> (<i>TPR2</i>), which encodes a co-chaperone. Expressing <i>TPR2</i> across ecotypes and genotypes showed consistent dosage effects. Each additional <i>TPR2</i><sup>Col-0</sup> allele increased seed mass and volume by 10-14% with high reliability in Col-0, Sha, Tsu-1, and <i>tsu2</i> genetic backgrounds. Reciprocal genetic crosses indicated that this locus acts maternally, consistent with female sporophytic or female gametophytic mutations. To e"],"journal":["International journal of molecular sciences"],"pubmed_title":["&lt;i&gt;Tetratricopeptide Repeat 2&lt;/i&gt; Is a Quantitative Trait Locus That Controls Seed Size."],"pmcid":["PMC12428041"],"funding_grant_id":["2008-35100-19244"],"pubmed_authors":["Cara S","Hauser BA","Rhee SY","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"&lt;i&gt;Tetratricopeptide Repeat 2&lt;/i&gt; Is a Quantitative Trait Locus That Controls Seed Size.","description":"Seed size is a key trait affecting evolution and agronomic performance by influencing seedling establishment in natural populations and crop yields. The <i>Arabidopsis thaliana</i> Seed Size QTL1 (SSQ1) locus explains 10-15% of the variation in seed size. We report here that the causal gene for this locus is <i>Tetratricopeptide Repeat Protein 2</i> (<i>TPR2</i>), which encodes a co-chaperone. Expressing <i>TPR2</i> across ecotypes and genotypes showed consistent dosage effects. Each additional <i>TPR2</i><sup>Col-0</sup> allele increased seed mass and volume by 10-14% with high reliability in Col-0, Sha, Tsu-1, and <i>tsu2</i> genetic backgrounds. Reciprocal genetic crosses indicated that this locus acts maternally, consistent with female sporophytic or female gametophytic mutations. To e","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-08T19:32:16.489Z","creation":"2026-04-08T13:55:45.734Z"},"accession":"S-EPMC12428041","cross_references":{"pubmed":["40943237"],"doi":["10.3390/ijms26178310"]}}