biostudies-literatureUnknown14(17)Pura L<h4>Background</h4>Chronic kidney disease (CKD) is largely driven by inflammation. Mesenchymal stem cells (MSCs) show therapeutic potential; however, their efficacy across CKD etiologies remains unclear.<h4>Methods</h4>Comprehensive searches were conducted in PubMed, Cochrane, ScienceDirect, Scopus and Google Scholar. Effect sizes for inflammation and renal function outcomes were meta-analyzed.<h4>Results</h4>Of 2514 studies screened, 52 met inclusion criteria (49 animal studies, 3 randomized controlled trials). In animal models, MSCs significantly reduced interleukin-6 (mean difference [MD] = -155.80; 95% CI: -249.10, -62.51; <i>p</i> = 0.001) and tumor necrosis factor-α (TNF-α) (MD = -35.53; 95% CI: -52.75, -18.30; <i>p</i> < 0.0001). In patients, TNF-α reduction was not significant (MD Cells1313https://www.ebi.ac.uk/biostudies/studies/S-EPMC12428256biostudies-literatureMesenchymal Stem Cells as Anti-Inflammatory Agents in Chronic Kidney Disease: A Systematic Review and Meta-Analysis.PMC12428256Putri RDPrahmana MABandiara RPura LFaried AWijaya MPSupriyadi RfalseMesenchymal Stem Cells as Anti-Inflammatory Agents in Chronic Kidney Disease: A Systematic Review and Meta-Analysis.<h4>Background</h4>Chronic kidney disease (CKD) is largely driven by inflammation. Mesenchymal stem cells (MSCs) show therapeutic potential; however, their efficacy across CKD etiologies remains unclear.<h4>Methods</h4>Comprehensive searches were conducted in PubMed, Cochrane, ScienceDirect, Scopus and Google Scholar. Effect sizes for inflammation and renal function outcomes were meta-analyzed.<h4>Results</h4>Of 2514 studies screened, 52 met inclusion criteria (49 animal studies, 3 randomized controlled trials). In animal models, MSCs significantly reduced interleukin-6 (mean difference [MD] = -155.80; 95% CI: -249.10, -62.51; <i>p</i> = 0.001) and tumor necrosis factor-α (TNF-α) (MD = -35.53; 95% CI: -52.75, -18.30; <i>p</i> < 0.0001). In patients, TNF-α reduction was not significant (MD 2025-01-01T00:00:00Z2025 Aug2026-04-08T19:11:02.627Z2026-04-08T12:05:49.395ZS-EPMC124282564094072410.3390/cells14171313