{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang R"],"funding":["Xinjiang Uygur Autonomous Region Major Science and Technology Special Project and the Central Guidance for Local Science and Technology Development Fund"],"pagination":["8239"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12428327"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(17)"],"pubmed_abstract":["This study aimed to assess the anti-inflammatory properties of mare milk by analyzing immune markers in mice following gavage of mare milk. Metagenomic sequencing was employed to examine variations in the composition and functional profiles of the intestinal microbiota across different experimental groups. Bacterial diversity, abundance, and functional annotations of gut microbiota were evaluated for each group. The results show that, compared to the control group, the mare milk group exhibited a significant decrease in the pro-inflammatory cytokine IL-6 levels and a significant increase in secretory immunoglobulin A (SIgA) levels (<i>p</i> < 0.05). The fermented mare milk group and the pasteurized fermented mare milk group demonstrated a significant downregulation of the pro-inflammatory "],"journal":["International journal of molecular sciences"],"pubmed_title":["Metagenomic Analysis Reveals the Anti-Inflammatory Properties of Mare Milk."],"pmcid":["PMC12428327"],"funding_grant_id":["2022A02007-1 and ZYYD2025JD02."],"pubmed_authors":["Ren W","Li Z","Ma S","Wang R","Liu S","Zeng Y","Yao X","Meng J","Li L","Wang J"],"additional_accession":[]},"is_claimable":false,"name":"Metagenomic Analysis Reveals the Anti-Inflammatory Properties of Mare Milk.","description":"This study aimed to assess the anti-inflammatory properties of mare milk by analyzing immune markers in mice following gavage of mare milk. Metagenomic sequencing was employed to examine variations in the composition and functional profiles of the intestinal microbiota across different experimental groups. Bacterial diversity, abundance, and functional annotations of gut microbiota were evaluated for each group. The results show that, compared to the control group, the mare milk group exhibited a significant decrease in the pro-inflammatory cytokine IL-6 levels and a significant increase in secretory immunoglobulin A (SIgA) levels (<i>p</i> < 0.05). The fermented mare milk group and the pasteurized fermented mare milk group demonstrated a significant downregulation of the pro-inflammatory ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-08T19:11:56.427Z","creation":"2026-04-08T12:03:42.978Z"},"accession":"S-EPMC12428327","cross_references":{"pubmed":["40943165"],"doi":["10.3390/ijms26178239"]}}