{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Chang SM"],"funding":["NIGMS NIH HHS","NIH HHS"],"pubmed_abstract":["Mitochondrial sirtuins regulate metabolism and are emerging drug targets for metabolic and age-related diseases such as cancer, diabetes, and neurodegeneration. Yet, the extent of their functions remain unclear. Here, we uncover a physiological role for the C. elegans mitochondrial sirtuins, sir-2.2 and sir-2.3, in lifespan regulation. Using genetic alleles with deletions that destroy catalytic activity, we demonstrate that sir-2.2 and sir-2.3 mutants live an average of 25% longer than controls when fed the normal lab diet of live E. coli OP50. While decreased consumption of food is a known mechanism for lifespan extension, we did not find evidence of reduced pharyngeal pumping. Interestingly, lifespan extension effected by loss of sir-2.2 or sir-2.3 is sensitive to the diet. The lifespan "],"journal":["Genetics"],"pagination":["iyaf185"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12428508"],"repository":["biostudies-literature"],"pubmed_title":["Mitochondrial sirtuins sir-2.2 and sir-2.3 regulate lifespan in C. elegans."],"pmcid":["PMC12428508"],"funding_grant_id":["R01 GM086786","P40 OD010440"],"pubmed_authors":["Sattar S","LaGanke NG","Hanna-Rose W","Franklin LP","Moro CA","DeGennaro MV","Chang SM"],"additional_accession":[]},"is_claimable":false,"name":"Mitochondrial sirtuins sir-2.2 and sir-2.3 regulate lifespan in C. elegans.","description":"Mitochondrial sirtuins regulate metabolism and are emerging drug targets for metabolic and age-related diseases such as cancer, diabetes, and neurodegeneration. Yet, the extent of their functions remain unclear. Here, we uncover a physiological role for the C. elegans mitochondrial sirtuins, sir-2.2 and sir-2.3, in lifespan regulation. Using genetic alleles with deletions that destroy catalytic activity, we demonstrate that sir-2.2 and sir-2.3 mutants live an average of 25% longer than controls when fed the normal lab diet of live E. coli OP50. While decreased consumption of food is a known mechanism for lifespan extension, we did not find evidence of reduced pharyngeal pumping. Interestingly, lifespan extension effected by loss of sir-2.2 or sir-2.3 is sensitive to the diet. The lifespan ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-02T10:06:39.963Z","creation":"2026-05-26T03:06:10.173Z"},"accession":"S-EPMC12428508","cross_references":{"pubmed":["40908783"],"doi":["10.1093/genetics/iyaf185"]}}