{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["26(17)"],"submitter":["Tseriotis VS"],"pubmed_abstract":["Cancer, a leading global cause of death responsible for nearly 10 million deaths annually, demands innovative therapeutic strategies. Intrinsic cytotoxicity and biocompatibility of zinc oxide nanoparticles (ZnO-NPs) have rendered them promising nanoplatforms in oncology. We herein systematically review their applications for targeted cancer chemotherapy, with a focus on physicochemical properties, drug delivery mechanisms, and interactions with the tumor microenvironment (TME). We searched PubMed, SCOPUS, and Web of Science from inception through December 2024 for peer-reviewed preclinical studies on cancer models. Results were qualitatively synthesized. Quality was assessed with the SYRCLE risk of bias tool. Among 20 eligible studies, ZnO-NPs were frequently functionalized with ligands to"],"journal":["International journal of molecular sciences"],"pagination":["8417"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12428772"],"repository":["biostudies-literature"],"pubmed_title":["ZnO-Based Nanoparticles for Targeted Cancer Chemotherapy and the Role of Tumor Microenvironment: A Systematic Review."],"pmcid":["PMC12428772"],"pubmed_authors":["Ampazis D","Tseriotis VS","Karachrysafi S","Sic A","Fouskas V","Mavropoulos P","Stergiou K","Kouvelas D","Pavlidis P","Lallas K","Papamitsou T","Petrakis G","Arnaoutoglou M"],"additional_accession":[]},"is_claimable":false,"name":"ZnO-Based Nanoparticles for Targeted Cancer Chemotherapy and the Role of Tumor Microenvironment: A Systematic Review.","description":"Cancer, a leading global cause of death responsible for nearly 10 million deaths annually, demands innovative therapeutic strategies. Intrinsic cytotoxicity and biocompatibility of zinc oxide nanoparticles (ZnO-NPs) have rendered them promising nanoplatforms in oncology. We herein systematically review their applications for targeted cancer chemotherapy, with a focus on physicochemical properties, drug delivery mechanisms, and interactions with the tumor microenvironment (TME). We searched PubMed, SCOPUS, and Web of Science from inception through December 2024 for peer-reviewed preclinical studies on cancer models. Results were qualitatively synthesized. Quality was assessed with the SYRCLE risk of bias tool. Among 20 eligible studies, ZnO-NPs were frequently functionalized with ligands to","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-08T19:35:26.619Z","creation":"2026-04-08T13:53:27.46Z"},"accession":"S-EPMC12428772","cross_references":{"pubmed":["40943339"],"doi":["10.3390/ijms26178417"]}}