{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["He L"],"funding":["Yunnan Fundamental Research Projects","Central Government Guidance Fund for the Development of Local Science and Technology"],"pagination":["8471"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12428871"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(17)"],"pubmed_abstract":["Neuromedin U receptors (NMURs) represent a class of evolutionarily conserved G-protein-coupled receptors that play a pivotal role in a variety of physiological processes. However, the role of NMURs in the heat shock response has yet to be elucidated. Using the nematode <i>Caenorhabditis elegans</i> as a model system, we demonstrate herein that functional loss of NMUR-3 results in reduced survival upon heat shock. The regulation of thermal tolerance by NMUR-3 is dependent on AMPK. Furthermore, our data demonstrate that NMUR-3 activates autophagy via AMPK, thereby contributing to protection against heat shock. The results of this study suggest that NMUR-3 is crucial for thermal tolerance in <i>C. elegans</i>."],"journal":["International journal of molecular sciences"],"pubmed_title":["Neuromedin U Receptor NMUR3 Regulates Autophagy, Thereby Enhancing Thermal Tolerance in &lt;i&gt;C. elegans&lt;/i&gt;."],"pmcid":["PMC12428871"],"funding_grant_id":["202401AS070137","202407AB110004","202501AS070173"],"pubmed_authors":["Yang J","Wang S","Ma Y","He L","Zou C"],"additional_accession":[]},"is_claimable":false,"name":"Neuromedin U Receptor NMUR3 Regulates Autophagy, Thereby Enhancing Thermal Tolerance in &lt;i&gt;C. elegans&lt;/i&gt;.","description":"Neuromedin U receptors (NMURs) represent a class of evolutionarily conserved G-protein-coupled receptors that play a pivotal role in a variety of physiological processes. However, the role of NMURs in the heat shock response has yet to be elucidated. Using the nematode <i>Caenorhabditis elegans</i> as a model system, we demonstrate herein that functional loss of NMUR-3 results in reduced survival upon heat shock. The regulation of thermal tolerance by NMUR-3 is dependent on AMPK. Furthermore, our data demonstrate that NMUR-3 activates autophagy via AMPK, thereby contributing to protection against heat shock. The results of this study suggest that NMUR-3 is crucial for thermal tolerance in <i>C. elegans</i>.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-08T19:10:38.867Z","creation":"2026-04-08T12:01:52.56Z"},"accession":"S-EPMC12428871","cross_references":{"pubmed":["40943393"],"doi":["10.3390/ijms26178471"]}}