biostudies-literatureHe LYunnan Fundamental Research ProjectsCentral Government Guidance Fund for the Development of Local Science and Technology8471https://www.ebi.ac.uk/biostudies/studies/S-EPMC12428871biostudies-literatureUnknown26(17)Neuromedin U receptors (NMURs) represent a class of evolutionarily conserved G-protein-coupled receptors that play a pivotal role in a variety of physiological processes. However, the role of NMURs in the heat shock response has yet to be elucidated. Using the nematode <i>Caenorhabditis elegans</i> as a model system, we demonstrate herein that functional loss of NMUR-3 results in reduced survival upon heat shock. The regulation of thermal tolerance by NMUR-3 is dependent on AMPK. Furthermore, our data demonstrate that NMUR-3 activates autophagy via AMPK, thereby contributing to protection against heat shock. The results of this study suggest that NMUR-3 is crucial for thermal tolerance in <i>C. elegans</i>.International journal of molecular sciencesNeuromedin U Receptor NMUR3 Regulates Autophagy, Thereby Enhancing Thermal Tolerance in &lt;i&gt;C. elegans&lt;/i&gt;.PMC12428871202401AS070137202407AB110004202501AS070173Yang JWang SMa YHe LZou CfalseNeuromedin U Receptor NMUR3 Regulates Autophagy, Thereby Enhancing Thermal Tolerance in &lt;i&gt;C. elegans&lt;/i&gt;.Neuromedin U receptors (NMURs) represent a class of evolutionarily conserved G-protein-coupled receptors that play a pivotal role in a variety of physiological processes. However, the role of NMURs in the heat shock response has yet to be elucidated. Using the nematode <i>Caenorhabditis elegans</i> as a model system, we demonstrate herein that functional loss of NMUR-3 results in reduced survival upon heat shock. The regulation of thermal tolerance by NMUR-3 is dependent on AMPK. Furthermore, our data demonstrate that NMUR-3 activates autophagy via AMPK, thereby contributing to protection against heat shock. The results of this study suggest that NMUR-3 is crucial for thermal tolerance in <i>C. elegans</i>.2025-01-01T00:00:00Z2025 Aug2026-04-08T19:10:38.867Z2026-04-08T12:01:52.56ZS-EPMC124288714094339310.3390/ijms26178471