biostudies-literatureUnknown2(3)Reiter R<h4>Introduction</h4>Assessment of intervertebral disc (IVD) degeneration on conventional magnetic resonance imaging (MRI) is limited by large inter-reader variability and lack of stratification in clinical trials and their assessment of treatment responses. Therefore, we aimed to introduce and diagnostically validate multifrequency magnetic resonance elastography (MRE) with tomoelastography processing for the assessment of lumbar IVD degeneration in healthy volunteers and patients with low back pain.<h4>Methods</h4>In this prospective single-center study, 60 participants (30 volunteers without low back pain and 30 patients with low back pain, 41 ± 17 years, body mass index 23.9 ± 3.7 kg/m², 25 women) underwent multifrequency MRE using vibration frequencies from 40 to 70 Hz usinRadiology advancesumaf013https://www.ebi.ac.uk/biostudies/studies/S-EPMC12429253biostudies-literatureIntervertebral disc degeneration of the lumbar spine assessed in vivo with 3T magnetic resonance tomoelastography.PMC12429253Bayerl CShahryari MBraun JLoch FNSack IReiter RStrehle RMurdel PKaufmann DAsbach PfalseIntervertebral disc degeneration of the lumbar spine assessed in vivo with 3T magnetic resonance tomoelastography.<h4>Introduction</h4>Assessment of intervertebral disc (IVD) degeneration on conventional magnetic resonance imaging (MRI) is limited by large inter-reader variability and lack of stratification in clinical trials and their assessment of treatment responses. Therefore, we aimed to introduce and diagnostically validate multifrequency magnetic resonance elastography (MRE) with tomoelastography processing for the assessment of lumbar IVD degeneration in healthy volunteers and patients with low back pain.<h4>Methods</h4>In this prospective single-center study, 60 participants (30 volunteers without low back pain and 30 patients with low back pain, 41 ± 17 years, body mass index 23.9 ± 3.7 kg/m², 25 women) underwent multifrequency MRE using vibration frequencies from 40 to 70 Hz usin2025-01-01T00:00:00Z2025 May2026-05-06T03:17:36.914Z2026-05-06T03:12:40.964ZS-EPMC124292534105915210.1093/radadv/umaf013