{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sala-Climent M"],"funding":["NCATS NIH HHS","Krupp Endowed Fund","NIA NIH HHS","NIAMS NIH HHS"],"pagination":["2729"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12430150"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(17)"],"pubmed_abstract":["<b>Introduction:</b> Osteoarthritis (OA) is a chronic degenerative joint disease with limited treatment options focused primarily on symptom management. Emerging evidence suggests that dietary interventions may influence inflammation and pain through modulation of the gut microbiome and metabolome. <b>Methods:</b> We conducted a 4-week open-label pilot trial evaluating the effects of an anti-inflammatory dietary intervention (ITIS diet) in 20 patients with knee OA (ClinicalTrials.gov ID: NCT05559463, registered prior to enrollment; sponsor: University of California, San Diego; responsible party: Monica Guma; study start date: 1 October 2021). The following were assessed before and after the intervention: (1) clinical outcomes; (2) gut and salivary microbiomes; and (3) salivary, stool, and "],"journal":["Nutrients"],"pubmed_title":["Targeted Microbial Shifts and Metabolite Profiles Were Associated with Clinical Response to an Anti-Inflammatory Diet in Osteoarthritis."],"pmcid":["PMC12430150"],"funding_grant_id":["R01 AG070647","NA","UL1 TR004419","T32 AR064194"],"pubmed_authors":["Mannochio-Russo H","Bu K","Dorrestein P","Guma M","Quan A","Murillo-Saich J","Clemente J","Sala-Climent M","Hose MK","Holt T","Nguyen K","Blank RB","Knight R","Scher J","Choi SI","Coras R","Lane NE","Cedeno M","Golshan S","Zuffa S","Allaband C"],"additional_accession":[]},"is_claimable":false,"name":"Targeted Microbial Shifts and Metabolite Profiles Were Associated with Clinical Response to an Anti-Inflammatory Diet in Osteoarthritis.","description":"<b>Introduction:</b> Osteoarthritis (OA) is a chronic degenerative joint disease with limited treatment options focused primarily on symptom management. Emerging evidence suggests that dietary interventions may influence inflammation and pain through modulation of the gut microbiome and metabolome. <b>Methods:</b> We conducted a 4-week open-label pilot trial evaluating the effects of an anti-inflammatory dietary intervention (ITIS diet) in 20 patients with knee OA (ClinicalTrials.gov ID: NCT05559463, registered prior to enrollment; sponsor: University of California, San Diego; responsible party: Monica Guma; study start date: 1 October 2021). The following were assessed before and after the intervention: (1) clinical outcomes; (2) gut and salivary microbiomes; and (3) salivary, stool, and ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-08T19:14:39.007Z","creation":"2026-04-08T12:08:49.966Z"},"accession":"S-EPMC12430150","cross_references":{"pubmed":["40944120"],"doi":["10.3390/nu17172729"]}}