{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Choi E"],"funding":["Korea Atomic Energy Research Institute","National Research Foundation of Korea"],"pagination":["3466"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12430447"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30(17)"],"pubmed_abstract":["Isoegomaketone [(<i>E</i>)-1-(furan-3-yl)-4-methylpent-2-en-1-one; <b>1</b>] is abundant in the essential oil of <i>Perilla</i> species and exhibits various biological activities, such as anticancer and anti-inflammatory effects. In order to discover compounds with reduced toxicity or enhanced biological activity through structural modification of natural product-derived components, isoegomaketone was irradiated with an electron beam at five different doses, and (±)-8-methoxy-perilla ketone (<b>2</b>) was obtained with the highest yield of 3.8% (<i>w</i>/<i>w</i>) at 80 kGy. Its structure was identified by one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution chemical ionization mass spectrometry. Compound <b>2</b> inhibited nitric oxide production"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Ionizing Radiation-Induced Structural Modification of Isoegomaketone and Its Anti-Inflammatory Activity."],"pmcid":["PMC12430447"],"funding_grant_id":["523320-24","2022R1A2C2013345"],"pubmed_authors":["Nam JW","Park J","Choi E","Jin CH","Huy Ngo T","Han AR"],"additional_accession":[]},"is_claimable":false,"name":"Ionizing Radiation-Induced Structural Modification of Isoegomaketone and Its Anti-Inflammatory Activity.","description":"Isoegomaketone [(<i>E</i>)-1-(furan-3-yl)-4-methylpent-2-en-1-one; <b>1</b>] is abundant in the essential oil of <i>Perilla</i> species and exhibits various biological activities, such as anticancer and anti-inflammatory effects. In order to discover compounds with reduced toxicity or enhanced biological activity through structural modification of natural product-derived components, isoegomaketone was irradiated with an electron beam at five different doses, and (±)-8-methoxy-perilla ketone (<b>2</b>) was obtained with the highest yield of 3.8% (<i>w</i>/<i>w</i>) at 80 kGy. Its structure was identified by one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution chemical ionization mass spectrometry. Compound <b>2</b> inhibited nitric oxide production","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Aug","modification":"2026-04-08T18:39:15.497Z","creation":"2026-04-08T10:05:06.765Z"},"accession":"S-EPMC12430447","cross_references":{"pubmed":["40941994"],"doi":["10.3390/molecules30173466"]}}