biostudies-literatureChoi EKorea Atomic Energy Research InstituteNational Research Foundation of Korea3466https://www.ebi.ac.uk/biostudies/studies/S-EPMC12430447biostudies-literatureUnknown30(17)Isoegomaketone [(<i>E</i>)-1-(furan-3-yl)-4-methylpent-2-en-1-one; <b>1</b>] is abundant in the essential oil of <i>Perilla</i> species and exhibits various biological activities, such as anticancer and anti-inflammatory effects. In order to discover compounds with reduced toxicity or enhanced biological activity through structural modification of natural product-derived components, isoegomaketone was irradiated with an electron beam at five different doses, and (±)-8-methoxy-perilla ketone (<b>2</b>) was obtained with the highest yield of 3.8% (<i>w</i>/<i>w</i>) at 80 kGy. Its structure was identified by one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution chemical ionization mass spectrometry. Compound <b>2</b> inhibited nitric oxide productionMolecules (Basel, Switzerland)Ionizing Radiation-Induced Structural Modification of Isoegomaketone and Its Anti-Inflammatory Activity.PMC12430447523320-242022R1A2C2013345Nam JWPark JChoi EJin CHHuy Ngo THan ARfalseIonizing Radiation-Induced Structural Modification of Isoegomaketone and Its Anti-Inflammatory Activity.Isoegomaketone [(<i>E</i>)-1-(furan-3-yl)-4-methylpent-2-en-1-one; <b>1</b>] is abundant in the essential oil of <i>Perilla</i> species and exhibits various biological activities, such as anticancer and anti-inflammatory effects. In order to discover compounds with reduced toxicity or enhanced biological activity through structural modification of natural product-derived components, isoegomaketone was irradiated with an electron beam at five different doses, and (±)-8-methoxy-perilla ketone (<b>2</b>) was obtained with the highest yield of 3.8% (<i>w</i>/<i>w</i>) at 80 kGy. Its structure was identified by one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy and high-resolution chemical ionization mass spectrometry. Compound <b>2</b> inhibited nitric oxide production2025-01-01T00:00:00Z2025 Aug2026-04-08T18:39:15.497Z2026-04-08T10:05:06.765ZS-EPMC124304474094199410.3390/molecules30173466