biostudies-literatureUnknown17(17)Sanmartin-Sanchez A<b>Background/Objetives</b>: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with poor prognosis. Nutritional disorders, particularly cachexia, significantly impact morbidity and mortality in IPF but remain under-investigated. This study aimed to characterize cachexia phenotypes in IPF through morphofunctional assessment (MFA) and to evaluate their prognostic relevance, including the role of mitochondrial biomarkers. <b>Methods</b>: In this prospective bicenter study, 85 IPF patients underwent MFA including bioelectrical impedance vector analysis (BIVA), nutritional ultrasound (NU), and T12-level computed tomography (T12-CT) for body composition. Functional and strength assessments included timed up and go test (TUG) and handgrip strength (HGS), respectively.Nutrients2739https://www.ebi.ac.uk/biostudies/studies/S-EPMC12430740biostudies-literatureCachexia Phenotyping Through Morphofunctional Assessment and Mitocondrial Biomarkers (GDF-15 and PGC-1α) in Idiopathic Pulmonary Fibrosis.PMC12430740Olivares-Alcolea JCornejo-Pareja IGarrido-Sanchez LSanchez-Garcia AVegas-Aguilar ICabrera-Cesar EEspildora-Hernandez FMurri MTinahones FJVelasco-Garrido JLGuirado-Pelaez PFernandez-Jimenez RAmaya-Campos MDMVillaplana-Garcia MGarcia-Almeida JMSimon-Frapolli VJSanmartin-Sanchez AVidal-Suarez AfalseCachexia Phenotyping Through Morphofunctional Assessment and Mitocondrial Biomarkers (GDF-15 and PGC-1α) in Idiopathic Pulmonary Fibrosis.<b>Background/Objetives</b>: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease with poor prognosis. Nutritional disorders, particularly cachexia, significantly impact morbidity and mortality in IPF but remain under-investigated. This study aimed to characterize cachexia phenotypes in IPF through morphofunctional assessment (MFA) and to evaluate their prognostic relevance, including the role of mitochondrial biomarkers. <b>Methods</b>: In this prospective bicenter study, 85 IPF patients underwent MFA including bioelectrical impedance vector analysis (BIVA), nutritional ultrasound (NU), and T12-level computed tomography (T12-CT) for body composition. Functional and strength assessments included timed up and go test (TUG) and handgrip strength (HGS), respectively.2025-01-01T00:00:00Z2025 Aug2026-04-23T03:23:03.877Z2026-04-23T03:11:57.056ZS-EPMC124307404094413010.3390/nu17172739