{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Thalhammer M"],"funding":["European Research Council","NIDA NIH HHS","Deutsche Forschungsgemeinschaft (German Research Foundation)","NIMH NIH HHS","Wellcome Trust"],"pagination":["8269"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12432136"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["The current view of neurodevelopment after preterm birth presents a strong paradox: diverse neurocognitive outcomes suggest heterogeneous neurodevelopment, yet numerous brain imaging studies focusing on average dysmaturation imply largely uniform aberrations across individuals. Here we show both, spatially heterogeneous individual brain abnormality patterns but with consistent underlying biological mechanisms of injury and plasticity. Using cross-sectional structural magnetic resonance imaging data from preterm neonates and longitudinal data from preterm children and adults in a normative reference framework, we demonstrate that brain development after preterm birth is highly heterogeneous in both severity and patterns of deviations. Individual brain abnormality patterns are also consistent for their extent and location along the life course, associated with glial cell underpinnings, and plastic for influences of the early social environment. Our findings extend conventional views of preterm neurodevelopment, revealing a nuanced landscape of individual variation, with consistent commonalities between subjects. This integrated perspective implies more targeted theranostic intervention strategies, specifically integrating brain charts and imaging at birth, as well as social interventions during early development."],"journal":["Nature communications"],"pubmed_title":["Heterogeneous, temporally consistent, and plastic brain development after preterm birth."],"pmcid":["PMC12432136"],"funding_grant_id":["U01 DA041117","U24 DA041123","U24 DA041147","319456","T32 MH019112","U01 DA041174","K08 MH120564","U01 DA041134","U01 DA041156","U01 DA041093","R33 DA027644","SO 1336/1-1","U01 DA051037","U01 DA041106","U01 DA041028","U01 DA041089","U01 DA041022","U01 DA041120","U01 DA041148","U01 DA041048","U01 DA041025","U01 DA051039","U01 DA051016","U01 DA051038","U01 DA051018","U01 DA050988","U54 MH091657","U01 DA050987","U01 DA050989"],"pubmed_authors":["Bethlehem RAI","Beare R","Bartmann P","Sorg C","Boecker H","Schmitz-Koep B","Hedderich DM","Ball G","Dorfschmidt L","Sa de Almeida J","Di Biase MA","Menegaux A","Schulz J","Neubauer A","Alexander-Bloch A","Zimmer C","Seidlitz J","Adamson C","Thalhammer M","Daamen M","Wolke D"],"additional_accession":[]},"is_claimable":false,"name":"Heterogeneous, temporally consistent, and plastic brain development after preterm birth.","description":"The current view of neurodevelopment after preterm birth presents a strong paradox: diverse neurocognitive outcomes suggest heterogeneous neurodevelopment, yet numerous brain imaging studies focusing on average dysmaturation imply largely uniform aberrations across individuals. Here we show both, spatially heterogeneous individual brain abnormality patterns but with consistent underlying biological mechanisms of injury and plasticity. Using cross-sectional structural magnetic resonance imaging data from preterm neonates and longitudinal data from preterm children and adults in a normative reference framework, we demonstrate that brain development after preterm birth is highly heterogeneous in both severity and patterns of deviations. Individual brain abnormality patterns are also consistent for their extent and location along the life course, associated with glial cell underpinnings, and plastic for influences of the early social environment. Our findings extend conventional views of preterm neurodevelopment, revealing a nuanced landscape of individual variation, with consistent commonalities between subjects. This integrated perspective implies more targeted theranostic intervention strategies, specifically integrating brain charts and imaging at birth, as well as social interventions during early development.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-02T08:48:45.471Z","creation":"2026-04-16T03:12:46.871Z"},"accession":"S-EPMC12432136","cross_references":{"pubmed":["40940320"],"doi":["10.1038/s41467-025-63967-1"]}}