{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Viswanathan M"],"funding":["NIBIB NIH HHS","National Institutes of Health","NIH HHS"],"pagination":["615-629"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12433017"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["91(2)"],"pubmed_abstract":["<h4>Purpose</h4>A new nuclear Overhauser enhancement (NOE)-mediated saturation transfer signal at around -1.6 ppm, termed NOE(-1.6), has been reported at high fields of 7T and 9.4T previously. This study aims to validate the presence of this signal at a relatively low field of 4.7T and evaluate its variations in different brain regions and tumors.<h4>Methods</h4>Rats were injected with monocrystalline iron oxide nanoparticles to reduce the NOE(-1.6) signal. CEST signals were measured using different saturation powers before and after injection to assess the presence of this signal. Multiple-pool Lorentzian fits, with/without inclusion of the NOE(-1.6) pool, were performed on CEST Z-spectra obtained from healthy rat brains and rats with 9L tumors. These fits aimed to further validate the presence of the NOE(-1.6) signal and quantify its amplitude.<h4>Results</h4>The NOE(-1.6) signal exhibited a dramatic change following the injection of monocrystalline iron oxide nanoparticles, confirming its presence at 4.7T. The NOE(-1.6) signal reached its peak at a saturation power of ∼0.75 μT, indicating an optimized power level. The multiple-pool Lorentzian fit without the NOE(-1.6) pool showed higher residuals around -1.6 ppm compared to the fit with this pool, further supporting the presence of this signal. The NOE(-1.6) signal did not exhibit significant variation in the corpus callosum and caudate putamen regions, but it showed a significant decrease in tumors, which aligns with previous findings at 9.4T.<h4>Conclusion</h4>This study successfully demonstrated the presence of the NOE(-1.6) signal at 4.7T, which provides valuable insights into its potential applications at lower field strengths."],"journal":["Magnetic resonance in medicine"],"pubmed_title":["Nuclear Overhauser enhancement imaging at -1.6 ppm in rat brain at 4.7T."],"pmcid":["PMC12433017"],"funding_grant_id":["R01 EB029443","S10 OD025085","R03 EB029078"],"pubmed_authors":["Viswanathan M","Kurmi Y","Zu Z"],"additional_accession":[]},"is_claimable":false,"name":"Nuclear Overhauser enhancement imaging at -1.6 ppm in rat brain at 4.7T.","description":"<h4>Purpose</h4>A new nuclear Overhauser enhancement (NOE)-mediated saturation transfer signal at around -1.6 ppm, termed NOE(-1.6), has been reported at high fields of 7T and 9.4T previously. This study aims to validate the presence of this signal at a relatively low field of 4.7T and evaluate its variations in different brain regions and tumors.<h4>Methods</h4>Rats were injected with monocrystalline iron oxide nanoparticles to reduce the NOE(-1.6) signal. CEST signals were measured using different saturation powers before and after injection to assess the presence of this signal. Multiple-pool Lorentzian fits, with/without inclusion of the NOE(-1.6) pool, were performed on CEST Z-spectra obtained from healthy rat brains and rats with 9L tumors. These fits aimed to further validate the presence of the NOE(-1.6) signal and quantify its amplitude.<h4>Results</h4>The NOE(-1.6) signal exhibited a dramatic change following the injection of monocrystalline iron oxide nanoparticles, confirming its presence at 4.7T. The NOE(-1.6) signal reached its peak at a saturation power of ∼0.75 μT, indicating an optimized power level. The multiple-pool Lorentzian fit without the NOE(-1.6) pool showed higher residuals around -1.6 ppm compared to the fit with this pool, further supporting the presence of this signal. The NOE(-1.6) signal did not exhibit significant variation in the corpus callosum and caudate putamen regions, but it showed a significant decrease in tumors, which aligns with previous findings at 9.4T.<h4>Conclusion</h4>This study successfully demonstrated the presence of the NOE(-1.6) signal at 4.7T, which provides valuable insights into its potential applications at lower field strengths.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Feb","modification":"2026-06-01T14:00:26.381Z","creation":"2026-04-08T13:16:10.409Z"},"accession":"S-EPMC12433017","cross_references":{"pubmed":["37867419"],"doi":["10.1002/mrm.29896"]}}