{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19"],"submitter":["Budny V"],"pubmed_abstract":["<h4>Introduction</h4>The main genetic risk factor for Alzheimer's disease (AD) is the presence of the apolipoprotein E4 (<i>APOE4</i>) allele. While <i>APOE4</i> increases the risk of developing AD, the <i>APOE2</i> allele is protective and <i>APOE3</i> is risk-neutral. In the brain, APOE is primarily expressed by astrocytes and plays a key role in various processes including cholesterol and lipid transport, neuronal growth, synaptic plasticity, immune response and energy metabolism. Disruptions in brain energy metabolism are considered a major contributor to AD pathophysiology, raising a key question about how different APOE isoforms affect the energy metabolism of human astrocytes.<h4>Methods</h4>In this study, we generated astrocytes (iAstrocytes) from <i>APOE</i>-isogenic human induced"],"journal":["Frontiers in cellular neuroscience"],"pagination":["1603657"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12434100"],"repository":["biostudies-literature"],"pubmed_title":["APOE genotype-dependent differences in human astrocytic energy metabolism."],"pmcid":["PMC12434100"],"pubmed_authors":["Barros LF","Rust R","Kruger M","Budny V","Zurcher KJ","Ruminot I","de Leeuw SM","Ravotto L","Weber RZ","Bodenmann C","Weber B","Tackenberg C"],"additional_accession":[]},"is_claimable":false,"name":"APOE genotype-dependent differences in human astrocytic energy metabolism.","description":"<h4>Introduction</h4>The main genetic risk factor for Alzheimer's disease (AD) is the presence of the apolipoprotein E4 (<i>APOE4</i>) allele. While <i>APOE4</i> increases the risk of developing AD, the <i>APOE2</i> allele is protective and <i>APOE3</i> is risk-neutral. In the brain, APOE is primarily expressed by astrocytes and plays a key role in various processes including cholesterol and lipid transport, neuronal growth, synaptic plasticity, immune response and energy metabolism. Disruptions in brain energy metabolism are considered a major contributor to AD pathophysiology, raising a key question about how different APOE isoforms affect the energy metabolism of human astrocytes.<h4>Methods</h4>In this study, we generated astrocytes (iAstrocytes) from <i>APOE</i>-isogenic human induced","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-02T05:25:51.03Z","creation":"2026-04-14T03:13:59.808Z"},"accession":"S-EPMC12434100","cross_references":{"pubmed":["40958776"],"doi":["10.3389/fncel.2025.1603657"]}}