{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Jiang X"],"pubmed_abstract":["<h4>Background</h4>Liver injury (LI) is responsible for a significant number of fatalities each year. In the context of Mongolian medicine, <i>Rhododendron molle</i> (Blume) G. Don (RM) is utilized for its properties to treatment of hepatic disorders. However, the underlying mechanisms of its action remain poorly understood.<h4>Objectives</h4>Clarifying the process through which RM enhances LI.<h4>Methods</h4>The chemical constituents were subjected to analysis, and network pharmacology alongside molecular docking studies were conducted. Additionally, ELISA, staining techniques, metabolomic analyses, and 16S rDNA sequencing were performed.<h4>Results</h4>A total of 17 components have been identified from RM, including liver disease-related compounds such as kaempferol, emodin, quercetin. N"],"journal":["Frontiers in microbiology"],"pagination":["1570229"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12434124"],"repository":["biostudies-literature"],"pubmed_title":["Integrative network pharmacology, metabolomics and gut flora studies reveal mechanisms of action of &lt;i&gt;Rhododendron molle&lt;/i&gt; (Blume) G. Don to ameliorate liver injury."],"pmcid":["PMC12434124"],"pubmed_authors":["Li X","Meng T","He D","Jiang X","Meng H","Chang H","Zhuang Y"],"additional_accession":[]},"is_claimable":false,"name":"Integrative network pharmacology, metabolomics and gut flora studies reveal mechanisms of action of &lt;i&gt;Rhododendron molle&lt;/i&gt; (Blume) G. Don to ameliorate liver injury.","description":"<h4>Background</h4>Liver injury (LI) is responsible for a significant number of fatalities each year. In the context of Mongolian medicine, <i>Rhododendron molle</i> (Blume) G. Don (RM) is utilized for its properties to treatment of hepatic disorders. However, the underlying mechanisms of its action remain poorly understood.<h4>Objectives</h4>Clarifying the process through which RM enhances LI.<h4>Methods</h4>The chemical constituents were subjected to analysis, and network pharmacology alongside molecular docking studies were conducted. Additionally, ELISA, staining techniques, metabolomic analyses, and 16S rDNA sequencing were performed.<h4>Results</h4>A total of 17 components have been identified from RM, including liver disease-related compounds such as kaempferol, emodin, quercetin. N","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-02T05:55:09.125Z","creation":"2026-04-15T03:09:35.228Z"},"accession":"S-EPMC12434124","cross_references":{"pubmed":["40959221"],"doi":["10.3389/fmicb.2025.1570229"]}}