biostudies-literatureKang MNational Institute on Aging Genetics of Alzheimer's Disease Data Storage SiteNIA NIH HHSNational Cell Repository for Alzheimer's DiseaseUniversity of Pennsylvania, funded by NIA, and the Religious Orders Study/Rush Memory and Aging ProjectNIH HHSAlzheimer's Disease Sequencing Project Phenotype Harmonization Consortiume70681https://www.ebi.ac.uk/biostudies/studies/S-EPMC12434708biostudies-literatureUnknown21(9)<h4>Introduction</h4>Identifying pleiotropy for blood pressure (BP) and cognitive performance measures may indicate mechanistic links between hypertension and Alzheimer's disease (AD).<h4>Methods</h4>We performed a pleiotropy genome-wide association study (GWAS) for paired measures of systolic, diastolic, pulse, and mean arterial pressure with memory, executive function, and language scores using 116,075 exam data from 25,726 participants in clinic-based and prospective cohorts. Significant findings were evaluated by Bayesian colocalization and differential gene expression in brain tissue from pathologically confirmed AD cases with and without clinical symptoms.<h4>Results</h4>Genome-wide significant pleiotropy for BP and cognitive performance with JPH2, GATA3, PAX2, LOC105371656, and SUFUAlzheimer's & dementia : the journal of the Alzheimer's AssociationGenome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures.PMC12434708R01-AG15819U24-AG021886R01-AG17917U01-AG082665P30-AG72975U01-AG032984U01-AG068057U01-AG081230P30-AG10161U24-AG074855R01-AG048927U54-AG052427U01-AG61356U01-AG058654U01-AG062602U01-AG46152P30-AG072878U24-AG041689R01-AG059716RF1-AG057519U19-AG068753Mez JScollard PLee MAng TFASchellenberg GDLunetta KLDumitrescu LCKukull WAHaines JLDevine SACuccaro MLPericak-Vance MAFarrer LAKang MAu RSherva RSaykin AJMayeux RPWang LSCrane PKKlinedinst BHohman TJNakano CBennett DAChoi SEMukherjee STrittschuh EHfalseGenome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures.<h4>Introduction</h4>Identifying pleiotropy for blood pressure (BP) and cognitive performance measures may indicate mechanistic links between hypertension and Alzheimer's disease (AD).<h4>Methods</h4>We performed a pleiotropy genome-wide association study (GWAS) for paired measures of systolic, diastolic, pulse, and mean arterial pressure with memory, executive function, and language scores using 116,075 exam data from 25,726 participants in clinic-based and prospective cohorts. Significant findings were evaluated by Bayesian colocalization and differential gene expression in brain tissue from pathologically confirmed AD cases with and without clinical symptoms.<h4>Results</h4>Genome-wide significant pleiotropy for BP and cognitive performance with JPH2, GATA3, PAX2, LOC105371656, and SUFU2025-01-01T00:00:00Z2025 Sep2026-06-03T02:55:44.591Z2026-04-23T03:13:15.648ZS-EPMC124347084095194610.1002/alz.70681