{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["39(18)"],"submitter":["Heinemann AS"],"pubmed_abstract":["Neutrophils play a vital role in human immune defense, and their dysregulation can cause collateral damage in sepsis and autoimmune diseases. We provide evidence for the involvement of the transient receptor potential vanilloid 2 (TRPV2) in cytokine expression and transmigration in human neutrophils as well as in HL60 cells. These data identify TRPV2 as a candidate target for novel therapeutics regulating neutrophil activity."],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pagination":["e71052"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12434796"],"repository":["biostudies-literature"],"pubmed_title":["TRPV2 Regulates Function of Human Neutrophil Granulocytes."],"pmcid":["PMC12434796"],"pubmed_authors":["Leffler A","Fricke TC","Heinemann AS","Herzog C","Echtermeyer FG"],"additional_accession":[]},"is_claimable":false,"name":"TRPV2 Regulates Function of Human Neutrophil Granulocytes.","description":"Neutrophils play a vital role in human immune defense, and their dysregulation can cause collateral damage in sepsis and autoimmune diseases. We provide evidence for the involvement of the transient receptor potential vanilloid 2 (TRPV2) in cytokine expression and transmigration in human neutrophils as well as in HL60 cells. These data identify TRPV2 as a candidate target for novel therapeutics regulating neutrophil activity.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-03T03:03:11.415Z","creation":"2026-04-23T03:14:08.894Z"},"accession":"S-EPMC12434796","cross_references":{"pubmed":["40948391"],"doi":["10.1096/fj.202501585RR"]}}