biostudies-literatureUnknown39(18)Heinemann ASNeutrophils play a vital role in human immune defense, and their dysregulation can cause collateral damage in sepsis and autoimmune diseases. We provide evidence for the involvement of the transient receptor potential vanilloid 2 (TRPV2) in cytokine expression and transmigration in human neutrophils as well as in HL60 cells. These data identify TRPV2 as a candidate target for novel therapeutics regulating neutrophil activity.FASEB journal : official publication of the Federation of American Societies for Experimental Biologye71052https://www.ebi.ac.uk/biostudies/studies/S-EPMC12434796biostudies-literatureTRPV2 Regulates Function of Human Neutrophil Granulocytes.PMC12434796Leffler AFricke TCHeinemann ASHerzog CEchtermeyer FGfalseTRPV2 Regulates Function of Human Neutrophil Granulocytes.Neutrophils play a vital role in human immune defense, and their dysregulation can cause collateral damage in sepsis and autoimmune diseases. We provide evidence for the involvement of the transient receptor potential vanilloid 2 (TRPV2) in cytokine expression and transmigration in human neutrophils as well as in HL60 cells. These data identify TRPV2 as a candidate target for novel therapeutics regulating neutrophil activity.2025-01-01T00:00:00Z2025 Sep2026-06-03T03:03:11.415Z2026-04-23T03:14:08.894ZS-EPMC124347964094839110.1096/fj.202501585RR