{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(12)"],"submitter":["Chen X"],"pubmed_abstract":["ANXA6 is involved in numerous biological processes; however, its association with recurrent spontaneous abortion (RSA) remains poorly understood. In this study, we observed significant upregulation of ANXA6 expression in decidual macrophages from RSA patients. Functional analysis revealed that ANXA6 overexpression enhanced reactive oxygen species (ROS) generation and reduced mitochondrial membrane potential, thereby promoting pyroptosis and upregulating M1 macrophage polarization markers. Mechanistically, inhibition of NLRP3 rescued ANXA6 overexpression-induced elevation of M1 polarization and pyroptosis in macrophages. In addition, inhibition of ROS alleviated the decreased mitochondrial membrane potential, aggravated macrophage pyroptosis, and exacerbated inflammatory response, as well a"],"journal":["International journal of biological sciences"],"pagination":["5206-5222"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12435268"],"repository":["biostudies-literature"],"pubmed_title":["ANXA6 Overexpression Causes Abnormal Decidual Macrophage-Trophoblast Crosstalk in Recurrent Spontaneous Abortion."],"pmcid":["PMC12435268"],"pubmed_authors":["Yang J","Zhang Y","Song QL","Chen X","Li XY","Ma XQ"],"additional_accession":[]},"is_claimable":false,"name":"ANXA6 Overexpression Causes Abnormal Decidual Macrophage-Trophoblast Crosstalk in Recurrent Spontaneous Abortion.","description":"ANXA6 is involved in numerous biological processes; however, its association with recurrent spontaneous abortion (RSA) remains poorly understood. In this study, we observed significant upregulation of ANXA6 expression in decidual macrophages from RSA patients. Functional analysis revealed that ANXA6 overexpression enhanced reactive oxygen species (ROS) generation and reduced mitochondrial membrane potential, thereby promoting pyroptosis and upregulating M1 macrophage polarization markers. Mechanistically, inhibition of NLRP3 rescued ANXA6 overexpression-induced elevation of M1 polarization and pyroptosis in macrophages. In addition, inhibition of ROS alleviated the decreased mitochondrial membrane potential, aggravated macrophage pyroptosis, and exacerbated inflammatory response, as well a","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-03T03:00:42.961Z","creation":"2026-04-23T03:13:37.849Z"},"accession":"S-EPMC12435268","cross_references":{"pubmed":["40959268"],"doi":["10.7150/ijbs.111791"]}}