{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rowntree LC"],"funding":["NIAID NIH HHS","Federal Government | DHAC | National Health and Medical Research Council (NHMRC)"],"pagination":["e2503145122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12435269"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["122(36)"],"pubmed_abstract":["Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been associated with asymptomatic SARS-CoV-2 infection in nonhospitalized individuals of European ancestry, with protective immunity attributed to preexisting cross-reactive CD8<sup>+</sup> T-cells directed against HLA-B*15:01-restricted Spike-derived S<sub>919-927</sub> peptide (B15/S<sub>919</sub><sup>+</sup>CD8<sup>+</sup> T-cells). However, fundamental questions remained on the abundance and clonotypic nature of CD8<sup>+</sup> T-cell responses in HLA-B*15:01-positive patients who succumbed to life-threatening COVID-19. Here, we analyzed B15/S<sub>919</sub><sup>+</sup>CD8<sup>+</sup> T-cell responses in COVID"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["HLA-B*15:01-positive severe COVID-19 patients lack CD8&lt;sup&gt;+&lt;/sup&gt; T cell pools with highly expanded public clonotypes."],"pmcid":["PMC12435269"],"funding_grant_id":["U01 AI144616","1173871"],"pubmed_authors":["Doherty PC","Rowntree LC","Kaewpreedee P","Peiris M","Sonehara K","Valkenburg SA","Habel JR","McKay MR","Kotsimbos TC","Gao GF","Juno JA","Kwok JSY","Cohen CA","Kent SJ","PHOSP-COVID Collaborative Group","Allen LF","McQuilten HA","Leung KSM","Thwaites RS","Xu J","Turtle L","Bond KA","Tosif S","Quadeer AA","Davies J","Lappas M","Kedzierska K","Thomas PG","Trubiano JA","Kaity Allen E","Lewin SR","Smibert OC","Gordon CL","Efstathiou C","Rossjohn J","Petersen J","Holmes NE","Chaurasia P","Namkoong H","Poon LLM","Wu JT","Ishii KJ","Liu WJ","Chan KKP","Pannaraj PS","Littler DR","Tian J","Cheng AC","Crawford NW","Thevarajan I","Hui DSC","Brightling CE","Zhang W","Lee CK","Okada Y","Lee KWK","Cheng SMS","Nguyen THO","Hagen RR","Williamson DA"],"additional_accession":[]},"is_claimable":false,"name":"HLA-B*15:01-positive severe COVID-19 patients lack CD8&lt;sup&gt;+&lt;/sup&gt; T cell pools with highly expanded public clonotypes.","description":"Understanding host factors driving asymptomatic versus severe disease outcomes is of key importance if we are to control emerging and re-emerging viral infections. HLA-B*15:01 has been associated with asymptomatic SARS-CoV-2 infection in nonhospitalized individuals of European ancestry, with protective immunity attributed to preexisting cross-reactive CD8<sup>+</sup> T-cells directed against HLA-B*15:01-restricted Spike-derived S<sub>919-927</sub> peptide (B15/S<sub>919</sub><sup>+</sup>CD8<sup>+</sup> T-cells). However, fundamental questions remained on the abundance and clonotypic nature of CD8<sup>+</sup> T-cell responses in HLA-B*15:01-positive patients who succumbed to life-threatening COVID-19. Here, we analyzed B15/S<sub>919</sub><sup>+</sup>CD8<sup>+</sup> T-cell responses in COVID","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Sep","modification":"2026-06-01T15:50:01.829Z","creation":"2026-04-08T13:50:39.264Z"},"accession":"S-EPMC12435269","cross_references":{"pubmed":["40892914"],"doi":["10.1073/pnas.2503145122"]}}